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Human NR2F6 activation kit by CRISPRa

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SKU
GA101440
NR2F6 CRISPRa kit - CRISPR gene activation of human nuclear receptor subfamily 2 group F member 6
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA806769 NR2F6 mouse monoclonal antibody, clone OTI2C9 (formerly 2C9) 100 ul
$447.00
RC201336 NR2F6 (Myc-DDK-tagged)-Human nuclear receptor subfamily 2, group F, member 6 (NR2F6)
10 ug
$686.00

Other products for "NR2F6"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol NR2F6
Locus ID 2063
Components

GA101440G1, NR2F6 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA101440G2, NR2F6 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA101440G3, NR2F6 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Shipping Ambient
Reference Data
RefSeq NM_005234
UniProt ID P10588
Synonyms EAR-2; EAR2; ERBAL2
Summary Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC).UniProtKB/Swiss-Prot Function
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Documents
Resources
Other Versions
SKU Description Size Price
KN201336 NR2F6 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN201336BN NR2F6 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN201336LP NR2F6 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN201336RB NR2F6 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN401336 NR2F6 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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