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Human DCTN1 activation kit by CRISPRa

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SKU
GA101155
DCTN1 CRISPRa kit - CRISPR gene activation of human dynactin subunit 1
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA349873 Rabbit Polyclonal Anti-DCTN1 Antibody
100 ul
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RC211975 DCTN1 (Myc-DDK-tagged)-Human dynactin 1 (DCTN1), transcript variant 1
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Other products for "DCTN1"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol DCTN1
Locus ID 1639
Components

GA101155G1, DCTN1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA101155G2, DCTN1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA101155G3, DCTN1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001135040, NM_001135041, NM_001190836, NM_001190837, NM_004082, NM_023019, NR_033935
UniProt ID Q14203
Synonyms DAP-150; DP-150; P135
Summary This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA). provided by RefSeq, Oct 2008
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Documents
Resources
Other Versions
SKU Description Size Price
KN411975 DCTN1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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