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Human Stefin B (CSTB) activation kit by CRISPRa

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SKU
GA101044
CSTB CRISPRa kit - CRISPR gene activation of human cystatin B
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

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RC203872 CSTB (Myc-DDK-tagged)-Human cystatin B (stefin B) (CSTB)
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Other products for "CSTB"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol CSTB
Locus ID 1476
Components

GA101044G1, Stefin B gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA101044G2, Stefin B gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA101044G3, Stefin B gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_000100
UniProt ID P04080
Synonyms CPI-B; CST6; EPM1; EPM1A; PME; STFB; ULD
Summary The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens. This gene encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1). One type of mutation responsible for EPM1 is the expansion in the promoter region of this gene of a CCCCGCCCCGCG repeat from 2-3 copies to 30-78 copies. provided by RefSeq, Jul 2016
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Documents
Resources
Other Versions
SKU Description Size Price
KN403872 CSTB - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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