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Human CD35 (CR1) activation kit by CRISPRa

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SKU
GA100965
CR1 CRISPRa kit - CRISPR gene activation of human complement C3b/C4b receptor 1 (Knops blood group)
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

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RC216533 CR1 (Myc-DDK-tagged)-Human complement component (3b/4b) receptor 1 (Knops blood group) (CR1), transcript variant F
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Other products for "CR1"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol CR1
Locus ID 1378
Components

GA100965G1, CD35 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA100965G2, CD35 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA100965G3, CD35 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_000573, NM_000651
UniProt ID P17927
Synonyms C3BR; C4BR; CD35; KN
Summary This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The genome is polymorphic at this locus with allele-specific splice variants encoding different isoforms, based on the presence/absence of long homologous repeats (LHRs). The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in this gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus, sarcoidosis and Alzheimer's disease. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. provided by RefSeq, May 2020
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Documents
Resources
Other Versions
SKU Description Size Price
KN216533 CR1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN216533BN CR1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN216533LP CR1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN216533RB CR1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN416533 CR1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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