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Human CCR5 activation kit by CRISPRa

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SKU
GA100870
CCR5 CRISPRa kit - CRISPR gene activation of human C-C motif chemokine receptor 5 (gene/pseudogene)
  $1,657.00
4 Weeks*

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Other products for "CCR5"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol CCR5
Locus ID 1234
Components

GA100870G1, CCR5 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA100870G2, CCR5 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA100870G3, CCR5 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_000579, NM_001100168
UniProt ID P51681
Synonyms CC-CKR-5; CCCKR5; CCR-5; CD195; CKR-5; CKR5; CMKBR5; IDDM22
Summary This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. An allelic polymorphism in this gene results in both functional and non-functional alleles; the reference genome represents the functional allele. Two transcript variants encoding the same protein have been found for this gene. provided by RefSeq, Jul 2015
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Documents
Resources
Other Versions
SKU Description Size Price
KN216008 CCR5 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN216008BN CCR5 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN216008LP CCR5 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN216008RB CCR5 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN416008 CCR5 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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