Human Calbindin (CALB1) activation kit by CRISPRa

SKU GA100554

CALB1 CRISPRa kit - CRISPR gene activation of human calbindin 1

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: CALB1
• Locus ID: 793
• Components:

  GA100554G1, Calbindin gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100554G2, Calbindin gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100554G3, Calbindin gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_004929, NM_001366795
• UniProt ID: P05937
• Synonyms: CALB; D-28K
• Summary: The protein encoded by this gene is a member of the calcium-binding protein superfamily that includes calmodulin and troponin C. Originally described as a 27 kDa protein, it is now known to be a 28 kDa protein. It contains four active calcium-binding domains, and has two modified domains that are thought to have lost their calcium binding capability. This protein is thought to buffer entry of calcium upon stimulation of glutamate receptors. Depletion of this protein was noted in patients with Huntington disease. [provided by RefSeq, Jan 2015]