Human ATP5MC2 activation kit by CRISPRa

SKU GA100359

ATP5MC2 CRISPRa kit - CRISPR gene activation of human ATP synthase membrane subunit c locus 2

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: ATP5MC2
• Locus ID: 517
• Components:

  GA100359G1, ATP5MC2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100359G2, ATP5MC2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100359G3, ATP5MC2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001002031, NM_001330269, NM_005176, NM_001369754, NM_001369757, NM_001369753, NM_001369755, NM_001369756, NM_001369758, NR_163135, NR_163136, NR_163137
• UniProt ID: Q06055
• Synonyms: ATP5A
• Summary: This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and single representatives of the gamma, delta, and epsilon subunits. The proton channel likely has nine subunits (a, b, c, d, e, f, g, F6 and 8). There are three separate genes which encode subunit c of the proton channel and they specify precursors with different import sequences but identical mature proteins. The protein encoded by this gene is one of three precursors of subunit c. This gene has multiple pseudogenes. [provided by RefSeq, Jan 2018]