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PD-L1 (CD274) (NM_014143) Human Tagged ORF Clone Lentiviral Particle

  • LentiORF®
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SKU
RC213071L1V
Lenti ORF particles, CD274 (Myc-DDK tagged) - Human CD274 molecule (CD274), 200ul, >10^7 TU/mL
file-pdf Biosafety Sheet
ORF Plasmid:
DDK tGFP
Lentiviral Particles:
DDK mGFP DDK w/ Puro mGFP w/ Puro
AAV Particle:
DDK
  $850.00
2 Weeks*
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Specifications
Specifications
Product Data
Type Human Tagged ORF Clone Lentiviral Particle
Tag Myc-DDK
Target Symbol PD-L1
Synonyms B7-H; B7H1; hPD-L1; PD-L1; PDCD1L1; PDCD1LG1; PDL1
Vector pLenti-C-Myc-DDK
Mammalian Cell Selection None
Sequence Data
ORF Nucleotide Sequence
The ORF insert of this clone is exactly the same as(RC213071).
ACCN NM_014143
ORF Size 870 bp
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Shipping Dry Ice
Reference Data
RefSeq NM_014143.2
RefSeq Size 1553 bp
RefSeq ORF 873 bp
Locus ID 29126
UniProt ID Q9NZQ7
Cytogenetics 9p24.1
Domains ig, IG
Protein Families Druggable Genome, Transmembrane
Protein Pathways Cell adhesion molecules (CAMs)
MW 33.28 kDa
Summary This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. provided by RefSeq, Sep 2015
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Documents
Resources

file-alt Citations

Selection and characterization of the novel anti-human PD-1 FV78 antibody from a targeted epitope mammalian cell-displayed antibody library
Luo, Wang, Lang et al
Cell. Mol. Immunol. (2016)
Cited by 12
AI Summary: OriGene’s CD274 (NM_014143) Human cDNA ORF Clone was used in this study to facilitate the expression of human PD-L1, enabling the characterization and screening of novel anti-PD-1 antibodies.
Snippet: USA). PEGFP-N1 and pDsRed2-1 were purchased from Clontech Laboratories, Inc (Madison, WI, USA). The CD274 (NM_014143) Human cDNA ORF Clone was purchased from OriGene Technologies (Rockville, MD, USA). The ... Cite SaveSaving
Showing 1-1 of 1 papers.
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