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PD-L1 (CD274) (NM_014143) Human Tagged ORF Clone Lentiviral Particle

  • LentiORF®
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SKU
RC213071L3V
Lenti ORF particles, CD274 (Myc-DDK tagged) - Human CD274 molecule (CD274), 200ul, >10^7 TU/mL
file-pdf Biosafety Sheet
ORF Plasmid:
DDK tGFP
Lentiviral Particles:
DDK w/ Puro DDK mGFP mGFP w/ Puro
AAV Particle:
DDK
  $850.00
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Specifications
Specifications
Product Data
Type Human Tagged ORF Clone Lentiviral Particle
Tag Myc-DDK
Target Symbol PD-L1
Synonyms B7-H; B7H1; hPD-L1; PD-L1; PDCD1L1; PDCD1LG1; PDL1
Vector pLenti-C-Myc-DDK-P2A-Puro
Mammalian Cell Selection Puromycin
Sequence Data
ORF Nucleotide Sequence
The ORF insert of this clone is exactly the same as(RC213071).
ACCN NM_014143
ORF Size 870 bp
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Shipping Dry Ice
Reference Data
RefSeq NM_014143.2
RefSeq Size 1553 bp
RefSeq ORF 873 bp
Locus ID 29126
UniProt ID Q9NZQ7
Cytogenetics 9p24.1
Domains ig, IG
Protein Families Druggable Genome, Transmembrane
Protein Pathways Cell adhesion molecules (CAMs)
MW 33.28 kDa
Summary This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. provided by RefSeq, Sep 2015
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Documents
Resources

file-alt Citations

Proteolytic processing of PD-L1 by ADAM proteases in breast cancer cells
Romero, Wise, Zolkiewska
Cancer Immunol. Immunother. (2019)
Cited by 93
AI Summary: OriGene’s human PD-L1 (NM_014143) lentiviral particles were used to stably overexpress PD-L1 in breast cancer cell lines, enabling the study of its proteolytic processing by ADAM proteases in this research.
Snippet: Stable overexpression of PD‑L1 Cells were plated in 12-well plates (1x105 cells/well). The next day, 2 ml of fresh media containing human PD-L1 (NM_014143) lentiviral particles (2x105 transducing units/ well;OriGene, Rockville, MD) and polybrene (8 μg/ml) were
Showing 1-1 of 1 papers.
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