BMP2 (NM_001200) Human Tagged ORF Clone
$489.00
$657.00
In Stock*
Specifications
| Product Data | |
| Type | Human Tagged ORF Clone |
|---|---|
| Target Symbol | BMP2 |
| Synonyms | BDA2; BMP2A; SSFSC; SSFSC1 |
| Vector | pCMV6-AC-GFP |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data | |
| Restriction Sites |
SgfI-MluI Cloning Scheme for this gene
|
Plasmid Map
|
| ACCN | NM_001200 |
| ORF Size | 1188 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_001200.1, NP_001191.1 |
| RefSeq Size | 1547 bp |
| RefSeq ORF | 1191 bp |
| Locus ID | 650 |
| UniProt ID | P12643 |
| Cytogenetics | 20p12.3 |
| Domains | TGF-beta, TGFb_propeptide |
| Protein Families | Adult stem cells, Cancer stem cells, Druggable Genome, Embryonic stem cells, ES Cell Differentiation/IPS, Induced pluripotent stem cells, Secreted Protein, Stem cell relevant signaling - TGFb/BMP signaling pathway, Transmembrane |
| Protein Pathways | Acute myeloid leukemia, Basal cell carcinoma, Cytokine-cytokine receptor interaction, Endocytosis, Hedgehog signaling pathway, Hematopoietic cell lineage, Melanogenesis, Pathways in cancer, TGF-beta signaling pathway |
| Summary | This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients. provided by RefSeq, Jul 2016 |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_001200" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC214586 | BMP2 (Myc-DDK-tagged)-Human bone morphogenetic protein 2 (BMP2) | 10 ug |
$457.00
|
|
| RC214586L1 | Lenti ORF clone of Human bone morphogenetic protein 2 (BMP2), Myc-DDK-tagged | 10 ug |
$757.00
|
|
| RC214586L2 | Lenti ORF clone of Human bone morphogenetic protein 2 (BMP2), mGFP tagged | 10 ug |
$757.00
|
|
| RC214586L3 | Lenti ORF clone of Human bone morphogenetic protein 2 (BMP2), Myc-DDK-tagged | 10 ug |
$757.00
|
|
| RC214586L4 | Lenti ORF clone of Human bone morphogenetic protein 2 (BMP2), mGFP tagged | 10 ug |
$757.00
|
|
| SC119392 | BMP2 (untagged)-Human bone morphogenetic protein 2 (BMP2) | 10 ug |
$457.00
|
|
Citations
Development of novel gene carrier using modified nano hydroxyapatite derived from equine bone for osteogenic differentiation of dental pulp stem cells
Lee, Seonwoo, Jang et al
Bioact Mater (2021) 6 (9), 2742-2751 DOI: 10.1016/j.bioactmat.2021.01.020
Lee, Seonwoo, Jang et al
Bioact Mater (2021) 6 (9), 2742-2751 DOI: 10.1016/j.bioactmat.2021.01.020
Cited by 29
AI Summary: In this study, OriGene’s BMP-2 plasmid and RUNX2, OCN, and OPN primers were used to evaluate and confirm the effectiveness of the newly developed gene carrier in promoting osteogenic differentiation of dental pulp stem cells.
Nanofibrous Scaffolds Containing Hydroxyapatite and Microfluidic-Prepared Polyamidoamin/BMP-2 Plasmid Dendriplexes for Bone Tissue Engineering Applications
Doosti-Telgerd, Mahdavi, Moradikhah et al
Int J Nanomedicine (2020) 15, 2633-2646 DOI: 10.2147/IJN.S244416
Doosti-Telgerd, Mahdavi, Moradikhah et al
Int J Nanomedicine (2020) 15, 2633-2646 DOI: 10.2147/IJN.S244416
Cited by 1
AI Summary: OriGene’s pCMV6-AC-GFP plasmid was used as the source of BMP-2 DNA for gene delivery experiments in the study, enabling the fabrication of scaffolds for bone tissue engineering applications.
Snippet: Materials and Methods. Plasmid DNA Preparation and Extraction. Plasmid DNA (pCMV6-AC-GFP, OriGene) containing BMP-2 sequence were amplified in Escherichia coli hot strain, DH5α, grown overnight in Luria-Broth base medium containing ampicillin
Showing 1-2 of 2 papers.
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