BMP2 (NM_001200) Human Untagged Clone
$457.00
In Stock*
Specifications
| Product Data | |
| Type | Human Untagged Clone |
|---|---|
| Target Symbol | BMP2 |
| Synonyms | BDA2; BMP2A; SSFSC; SSFSC1 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data | |
| Restriction Sites | NotI-NotI | |
| ACCN | NM_001200 |
| Insert Size | 2000 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_001200.1, NP_001191.1 |
| RefSeq Size | 1547 bp |
| RefSeq ORF | 1191 bp |
| Locus ID | 650 |
| UniProt ID | P12643 |
| Cytogenetics | 20p12.3 |
| Domains | TGF-beta, TGFb_propeptide |
| Protein Families | Adult stem cells, Cancer stem cells, Druggable Genome, Embryonic stem cells, ES Cell Differentiation/IPS, Induced pluripotent stem cells, Secreted Protein, Stem cell relevant signaling - TGFb/BMP signaling pathway, Transmembrane |
| Protein Pathways | Acute myeloid leukemia, Basal cell carcinoma, Cytokine-cytokine receptor interaction, Endocytosis, Hedgehog signaling pathway, Hematopoietic cell lineage, Melanogenesis, Pathways in cancer, TGF-beta signaling pathway |
| Summary | This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients. provided by RefSeq, Jul 2016 |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_001200" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC214586 | BMP2 (Myc-DDK-tagged)-Human bone morphogenetic protein 2 (BMP2) | 10 ug |
$457.00
|
|
| RC214586L1 | Lenti ORF clone of Human bone morphogenetic protein 2 (BMP2), Myc-DDK-tagged | 10 ug |
$757.00
|
|
| RC214586L2 | Lenti ORF clone of Human bone morphogenetic protein 2 (BMP2), mGFP tagged | 10 ug |
$757.00
|
|
| RC214586L3 | Lenti ORF clone of Human bone morphogenetic protein 2 (BMP2), Myc-DDK-tagged | 10 ug |
$757.00
|
|
| RC214586L4 | Lenti ORF clone of Human bone morphogenetic protein 2 (BMP2), mGFP tagged | 10 ug |
$757.00
|
|
| RG214586 | BMP2 (tGFP-tagged) - Human bone morphogenetic protein 2 (BMP2) | 10 ug |
$489.00
$657.00
|
|
Citations
Comparison of In-Situ versus Ex-Situ Delivery of Polyethylenimine-BMP-2 polyplexes for Rat Calvarial Defect Repair via Intraoperative Bioprinting
Moncal, Yeo, Celik et al
Biofabrication (2022) 15 (1), 015011 DOI: 10.1088/1758-5090/ac9f70
Moncal, Yeo, Celik et al
Biofabrication (2022) 15 (1), 015011 DOI: 10.1088/1758-5090/ac9f70
Cited by 17
AI Summary: OriGene’s pBMP-2 plasmid DNA (cat. no. SC119392) was used in this study to generate the gene delivery complexes essential for comparing in-situ and ex-situ strategies for bone defect repair.
Snippet: … Briefly, the chemically 17 competent DH5αTM bacterial strain (Escherichia colispecies) was transformed with pBMP-2 (cat. 18 no. SC119392, Origene Technologies, Rockville, MD). …
Controlled Co-delivery of pPDGF-B and pBMP-2 from intraoperatively bioprinted bone constructs improves the repair of calvarial defects in rats
Moncal, Tigli Aydın, Godzik et al
Biomaterials (2021) 281, 121333 DOI: 10.1016/j.biomaterials.2021.121333
Moncal, Tigli Aydın, Godzik et al
Biomaterials (2021) 281, 121333 DOI: 10.1016/j.biomaterials.2021.121333
Cited by 70
AI Summary: OriGene products, specifically the pPDGF-B plasmid (catalog number SC119392), were used as gene delivery vectors to encode platelet-derived growth factor-B, enabling the controlled release of growth factors from bioprinted bone constructs for enhanced calvarial defect repair in rats.
Snippet: SC119392, Origene technologies). The further information about the inserted genes, the plasmid vectors and the maps can be can be reached from Origene technologies (Rockville, MD, USA). The transformed cultures were then expanded in Lennox L Broth (
Non-viral gene delivery embedded in biomimetically mineralized matrices for bone tissue engineering
Acri, Laird, Jaidev et al
Tissue Eng Part A (2020)
Acri, Laird, Jaidev et al
Tissue Eng Part A (2020)
AI Summary: OriGene contributed pFGF-2 plasmid (No. SC118884) and pBMP-2 plasmid (No. SC119392) to this study, enabling the investigation of growth factor gene delivery for enhanced bone regeneration in biomimetically mineralized matrices.
Snippet: 13031 open read frame [ORF] ref LC337019.1;Addgene, Watertown, MA) and the pFGF-2 and pBMP-2 were purchased from OriGene (Rockville, MD;FGF-2 plasmid No. SC118884 ORF ref NM_002006.3, BMP-2 plasmid No;- plasmid #13031 ORF ref LC337019.1) and the pFGF-2 and pBMP-2 were purchased from OriGene (Rockville, MD, FGF-2 plasmid #SC118884 ORF ref NM_002006.3, BMP-2 plasmid #SC119392 ORF ref NM_001200.1). …
A Multi-Functional Implant Induces Bone Formation in a Diabetic Model
Khorsand, Acri, Do et al
Adv Healthc Mater (2020) 9 (18), e2000770 DOI: 10.1002/adhm.202000770
Khorsand, Acri, Do et al
Adv Healthc Mater (2020) 9 (18), e2000770 DOI: 10.1002/adhm.202000770
Cited by 17
AI Summary: OriGene Technologies supplied the plasmid DNA encoding BMP-2 and FGF-2, which were essential components used for gene delivery to promote bone regeneration in the diabetic rat model described in the study.
Snippet: Abstract Patients with diabetes mellitus (DM) have defective healing of bone fractures. It was previously shown that nonviral gene delivery of plasmid DNA (pDNA) that independently encodes bone mor...;INS from bovine pancreas powder and 1𝛼,25- dihydroxyvitamin D3 (activated VD3) were acquired from Sigma-Aldrich. Branched PEI (molecular weight: 25 kDa) and the GenElute HP endotoxinfree plasmid maxi...
Histone-targeted gene transfer of bone morphogenetic protein-2 enhances mesenchymal stem cell chondrogenic differentiation
Munsell, Kurpad, Freeman et al
Acta Biomater (2018)
Munsell, Kurpad, Freeman et al
Acta Biomater (2018)
AI Summary: OriGene contributed to this study by providing the pCMV6-XL4 mammalian expression plasmid encoding BMP-2, which was used to facilitate gene transfer and enhance chondrogenic differentiation of mesenchymal stem cells.
Snippet: Shimadzu Inc. (Columbia, MD) through a Viva C18 column from Restek (Lancaster, PA). The pCMV6-XL4 mammalian expression plasmid encoding BMP-2 was obtained from OriGene Technologies (Rockville, MD). The gWIZ
Modification of Human Umbilical Cord Blood Stem Cells Using Polyethylenimine Combined with Modified TAT Peptide to Enhance BMP-2 Production
Wang, You, Wei et al
Biomed Res Int (2017) 2017, 2971413 DOI: 10.1155/2017/2971413
Wang, You, Wei et al
Biomed Res Int (2017) 2017, 2971413 DOI: 10.1155/2017/2971413
Cited by 9
AI Summary: In this study, OriGene's BMP-2 ELISA kit (Cat# EK0464) was used to quantitatively measure BMP-2 protein levels in transfected human umbilical cord blood stem cells, helping to assess the effectiveness of gene delivery and BMP-2 production.
Showing 1-6 of 9 papers.
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