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BMP2 (NM_001200) Human Tagged ORF Clone Lentiviral Particle

  • LentiORF®
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SKU
RC214586L1V
Lenti ORF particles, BMP2 (Myc-DDK tagged) - Human bone morphogenetic protein 2 (BMP2), 200ul, >10^7 TU/mL
file-pdf Biosafety Sheet
ORF Plasmid:
DDK tGFP
Lentiviral Particles:
DDK mGFP DDK w/ Puro mGFP w/ Puro
AAV Particle:
DDK
  $1,007.00
3 Weeks*
Bulk Requests & Clone Modifications

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Specifications
Specifications
Product Data
Type Human Tagged ORF Clone Lentiviral Particle
Tag Myc-DDK
Target Symbol BMP2
Synonyms BDA2; BMP2A; SSFSC; SSFSC1
Vector pLenti-C-Myc-DDK
Mammalian Cell Selection None
Sequence Data
ORF Nucleotide Sequence
The ORF insert of this clone is exactly the same as(RC214586).
ACCN NM_001200
ORF Size 1188 bp
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Shipping Dry Ice
Reference Data
RefSeq NM_001200.1
RefSeq Size 1547 bp
RefSeq ORF 1191 bp
Locus ID 650
UniProt ID P12643
Cytogenetics 20p12.3
Domains TGF-beta, TGFb_propeptide
Protein Families Adult stem cells, Cancer stem cells, Druggable Genome, Embryonic stem cells, ES Cell Differentiation/IPS, Induced pluripotent stem cells, Secreted Protein, Stem cell relevant signaling - TGFb/BMP signaling pathway, Transmembrane
Protein Pathways Acute myeloid leukemia, Basal cell carcinoma, Cytokine-cytokine receptor interaction, Endocytosis, Hedgehog signaling pathway, Hematopoietic cell lineage, Melanogenesis, Pathways in cancer, TGF-beta signaling pathway
MW 44.63 kDa
Summary This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients. provided by RefSeq, Jul 2016
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Documents
Resources

file-alt Citations

Two novel BMP-2 variants identified in patients with thoracic ossification of the ligamentum flavum
Qu, Chen, Fan et al
Eur. J. Hum. Genet. (2017)
AI Summary: OriGene’s pCMV6-Entry vector carrying human BMP-2 cDNA ORF with a C-terminal myc-DDK-tag was used in this study to express wild-type BMP-2 for functional assays investigating the impact of novel BMP-2 variants in patients with thoracic ossification of the ligamentum flavum.
Snippet: Plasmid transfection and western blot analysis. The pCMV6-Entry vector carrying the human BMP-2 cDNA ORF and the C-terminal myc-DDK-tag (referred to as WT) was purchased from OriGene Technologies (Beijing, China). ... All 3 versions Cite SaveSaving
WB
Showing 1-1 of 1 papers.
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