c-Myc (MYC) (NM_002467) Human Tagged ORF Clone
$686.00
In Stock*
Specifications
| Product Data | |
| Type | Human Tagged ORF Clone |
|---|---|
| Target Symbol | c-Myc |
| Synonyms | bHLHe39; c-Myc; MRTL; MYCC |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data | |
| Chromatograms |
Chromatograms
 Sequencher program is needed, download here |
| Restriction Sites |
SgfI-MluI Cloning Scheme for this gene
|
Plasmid Map
|
| ACCN | NM_002467 |
| ORF Size | 1362 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_002467.6 |
| RefSeq Size | 2379 bp |
| RefSeq ORF | 1365 bp |
| Locus ID | 4609 |
| UniProt ID | P01106 |
| Cytogenetics | 8q24.21 |
| Domains | HLH, Myc-LZ, Myc_N_term |
| Protein Families | Druggable Genome, Embryonic stem cells, Induced pluripotent stem cells, Stem cell - Pluripotency, Stem cell relevant signaling - JAK/STAT signaling pathway, Stem cell relevant signaling - TGFb/BMP signaling pathway, Stem cell relevant signaling - Wnt Signaling pathway, Transcription Factors |
| Protein Pathways | Acute myeloid leukemia, Bladder cancer, Cell cycle, Chronic myeloid leukemia, Colorectal cancer, Endometrial cancer, ErbB signaling pathway, Jak-STAT signaling pathway, MAPK signaling pathway, Pathways in cancer, Small cell lung cancer, TGF-beta signaling pathway, Thyroid cancer, Wnt signaling pathway |
| MW | 50.5 kDa |
| Summary | This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini. provided by RefSeq, Aug 2017 |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_002467" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC201611L1 | Lenti ORF clone of Human v-myc myelocytomatosis viral oncogene homolog (avian) (MYC), Myc-DDK-tagged | 10 ug |
$986.00
|
|
| RC201611L2 | Lenti ORF clone of Human v-myc myelocytomatosis viral oncogene homolog (avian) (MYC), mGFP tagged | 10 ug |
$986.00
|
|
| RC201611L3 | Lenti ORF clone of Human v-myc myelocytomatosis viral oncogene homolog (avian) (MYC), Myc-DDK-tagged | 10 ug |
$986.00
|
|
| RC201611L4 | Lenti ORF clone of Human v-myc myelocytomatosis viral oncogene homolog (avian) (MYC), mGFP tagged | 10 ug |
$986.00
|
|
| RG201611 | MYC (tGFP-tagged) - Human v-myc myelocytomatosis viral oncogene homolog (avian) (MYC) | 10 ug |
$886.00
|
|
| SC112715 | MYC (untagged)-Human v-myc myelocytomatosis viral oncogene homolog (avian) (MYC) | 10 ug |
$686.00
|
|
Citations
SLFN14 functions as a P-TEFb inhibitor to modulate the transcription of HIV-1 and cellular genes
Chen, Ma, Wang et al
Sci Adv (2025) 11 (51), eadt7982 DOI: 10.1126/sciadv.adt7982
Chen, Ma, Wang et al
Sci Adv (2025) 11 (51), eadt7982 DOI: 10.1126/sciadv.adt7982
Cited by 1
AI Summary: In this study, OriGene’s human-tagged ORF clones for NF-kB p65 (RELA), c-Myc (MYC), and CIITA were used to investigate the molecular mechanisms by which SLFN14 inhibits P-TEFb and modulates HIV-1 and cellular gene transcription.
Snippet: NF-kB p65 (RELA) (NM_021975) Human-tagged ORF clone OriGene Catalog no. RC220780 c-Myc (MYC) (NM_002467) human-tagged ORF clone OriGene Catalog no. RC201611 CIITA (NM_000246) human-tagged ORF clone OriGene Catalog no. RC222253
Upregulation of Myc promotes the evasion of NK cell‑mediated immunity through suppression of NKG2D ligands in K562 cells
Lee, Heo, Son et al
Mol Med Rep (2019) 20 (4), 3301-3307 DOI: 10.3892/mmr.2019.10583
Lee, Heo, Son et al
Mol Med Rep (2019) 20 (4), 3301-3307 DOI: 10.3892/mmr.2019.10583
AI Summary: OriGene's pCMV6 and pCMV6-myc vectors were used to overexpress c-Myc in K562 cells, enabling the study of how c-Myc upregulation affects NK cell-mediated immunity in this research.
Snippet: c‑Myc overexpression in K562 cells using pCMV6 vector. pcMV6 and pcMV6‑myc vectors were purchased from Origene. Each vector was transfected into K562 cells using Xfect Transfection reagent (clontech) by following the manufacturer's protocol
Downregulation of miR-16 via URGCP pathway contributes to glioma growth
Hong, Qing, Ji et al
Sci Rep (2017) 7 (1), 13470 DOI: 10.1038/s41598-017-14035-2
Hong, Qing, Ji et al
Sci Rep (2017) 7 (1), 13470 DOI: 10.1038/s41598-017-14035-2
AI Summary: OriGene products—specifically human RALA/p65, URGCP, and c-myc cDNAs—were used to construct expression plasmids that enabled the investigation of the molecular mechanisms underlying glioma growth in this study.
Snippet: …Human RALA/p65, URGCP and c-myc cDNAs were purchased from OriGene (USA) and inserted into pLenti-C-mGFP vectors. ...;... …Human RALA/p65, URGCP and c-myc cDNAs were purchased from OriGene (USA) and inserted into pLenti-C-mGFP vectors.
MYC is a positive regulator of choline metabolism and impedes mitophagy-dependent necroptosis in diffuse large B-cell lymphoma
Xiong, Wang, Fei et al
Blood Cancer J (2017) 7 (7), e0 DOI: 10.1038/bcj.2017.61
Xiong, Wang, Fei et al
Blood Cancer J (2017) 7 (7), e0 DOI: 10.1038/bcj.2017.61
AI Summary: OriGene products, including the PCYT1A-overexpressing vector (pCMV6-PCYT1A), MYC-overexpressing vector (pCMV6-MYC), control vector (pCMV6-ct), and shRNA, were used to manipulate gene expression and investigate the roles of MYC and PCYT1A in choline metabolism and necroptosis in diffuse large B-cell lymphoma cells.
Snippet: son, WI, USA), PCYT1A-overexpressing vector pCMV6-PCYT1A, MYC-. overexpressing vector pCMV6-MYC or vehicle pCMV6-ct (Origene, Rock-. ... shRNA (Origene) using HiperFect transfection reagent (Qiagen) according. to manufacturer's instruction. Western blotting ... All 3 versions Cite SaveSaving
Aspirin and salicylic acid decrease c-Myc expression in cancer cells: a potential role in chemoprevention
Ai, Dachineni, Muley et al
Tumour Biol. (2015)
Ai, Dachineni, Muley et al
Tumour Biol. (2015)
Cited by 45
AI Summary: OriGene’s DDK-tagged c-Myc full-length cDNA was used in this study to assess the effects of aspirin and salicylic acid on exogenously expressed c-Myc protein levels in cancer cells.
Snippet: Lactacystin and calpeptin were obtained from EMD Millipore;DDK-tagged c-Myc full- length cDNA was obtained from Origene Inc.;FuGENE trans- fection reagent was from Promega;random primer DNA la- beling kit was from Takara Biotech;32P γ-ATP was from MP ... Cite SaveSaving
Showing 1-5 of 5 papers.
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