c-Myc (MYC) (NM_002467) Human Untagged Clone
$686.00
In Stock*
Specifications
| Product Data | |
| Type | Human Untagged Clone |
|---|---|
| Target Symbol | c-Myc |
| Synonyms | bHLHe39; c-Myc; MRTL; MYCC |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data | |
| Restriction Sites | ECoRI-NOT | |
| ACCN | NM_002467 |
| Insert Size | 1365 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_002467.3, NP_002458.2 |
| RefSeq Size | 2377 bp |
| RefSeq ORF | 1365 bp |
| Locus ID | 4609 |
| UniProt ID | P01106 |
| Cytogenetics | 8q24.21 |
| Domains | HLH, Myc-LZ, Myc_N_term |
| Protein Families | Druggable Genome, Embryonic stem cells, Induced pluripotent stem cells, Stem cell - Pluripotency, Stem cell relevant signaling - JAK/STAT signaling pathway, Stem cell relevant signaling - TGFb/BMP signaling pathway, Stem cell relevant signaling - Wnt Signaling pathway, Transcription Factors |
| Protein Pathways | Acute myeloid leukemia, Bladder cancer, Cell cycle, Chronic myeloid leukemia, Colorectal cancer, Endometrial cancer, ErbB signaling pathway, Jak-STAT signaling pathway, MAPK signaling pathway, Pathways in cancer, Small cell lung cancer, TGF-beta signaling pathway, Thyroid cancer, Wnt signaling pathway |
| Summary | This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini. provided by RefSeq, Aug 2017 |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_002467" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC201611 | MYC (Myc-DDK-tagged)-Human v-myc myelocytomatosis viral oncogene homolog (avian) (Myc) | 10 ug |
$686.00
|
|
| RC201611L1 | Lenti ORF clone of Human v-myc myelocytomatosis viral oncogene homolog (avian) (MYC), Myc-DDK-tagged | 10 ug |
$986.00
|
|
| RC201611L2 | Lenti ORF clone of Human v-myc myelocytomatosis viral oncogene homolog (avian) (MYC), mGFP tagged | 10 ug |
$986.00
|
|
| RC201611L3 | Lenti ORF clone of Human v-myc myelocytomatosis viral oncogene homolog (avian) (MYC), Myc-DDK-tagged | 10 ug |
$986.00
|
|
| RC201611L4 | Lenti ORF clone of Human v-myc myelocytomatosis viral oncogene homolog (avian) (MYC), mGFP tagged | 10 ug |
$986.00
|
|
| RG201611 | MYC (tGFP-tagged) - Human v-myc myelocytomatosis viral oncogene homolog (avian) (MYC) | 10 ug |
$886.00
|
|
Citations
MYC-binding lncRNA EPIC1 promotes AKT-mTORC1 signaling and rapamycin resistance in breast and ovarian cancer
Wang, Zhang, Wang et al
Mol. Carcinog. (2020) 59 (10), 1188-1198 DOI: 10.1002/mc.23248
Wang, Zhang, Wang et al
Mol. Carcinog. (2020) 59 (10), 1188-1198 DOI: 10.1002/mc.23248
Cited by 14
AI Summary: OriGene’s human MYC cDNA clone (#SC112715) was used as a template to generate Flag-tagged MYC expression vectors, enabling the study of MYC’s role in EPIC1-mediated activation of the AKT-mTORC1 signaling pathway and rapamycin resistance in breast and ovarian cancer cells.
Snippet: Full length of Flag‐tagged MYC expression vectors were generated using a human MYC complementary DNA (cDNA) Clone (#SC112715;OriGene) as a DNA template. 2.3 Sodium dodecyl sulfate‐polyacrylamide gel electrophoresis and Western blot;- Full length of Flag‐tagged MYC expression vectors were generated using a human MYC complementary DNA (cDNA) Clone (#SC112715
c-Myc shuttled by tumour-derived extracellular vesicles promotes lung bronchial cell proliferation through miR-19b and miR-92a
Borzi, Calzolari, Ferretti et al
Cell Death Dis (2019) 10 (10), 759 DOI: 10.1038/s41419-019-2003-5
Borzi, Calzolari, Ferretti et al
Cell Death Dis (2019) 10 (10), 759 DOI: 10.1038/s41419-019-2003-5
AI Summary: OriGene’s human MYC plasmid construct (SC112715, pCMV6-XL5-MYC) was used to transiently overexpress c-Myc in HBEC-KRASV12high cells, enabling the study of c-Myc’s role in promoting bronchial cell proliferation through miR-19b and miR-92a.
Snippet: Denmark) was performed 24 h before EV or EV-depleted CM treatment (indicated as LNA EVs and LNA CM-EVs depleted, respectively), as described above. A human MYC plasmid construct was purchased from OriGene (SC112715, pCMV6-XL5-MYC;OriGene Technologies, Rockville, MD, USA) and transiently transfected into HBEC-KRASV12high cells following the company’s protocol. Cells were collected at 24 or 72
lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer
Wang, Yang, Zhang et al
Cancer Cell (2018) 33 (4), 706-720.e9 DOI: 10.1016/j.ccell.2018.03.006
Wang, Yang, Zhang et al
Cancer Cell (2018) 33 (4), 706-720.e9 DOI: 10.1016/j.ccell.2018.03.006
AI Summary: In this study, OriGene’s EPIC1 overexpression plasmid (RC204307) and EPIC1 shRNA lentiviral particles (TL313525V) were used to modulate EPIC1 expression in cancer cell lines, enabling the authors to investigate EPIC1’s role in promoting cell-cycle progression and tumor growth.
Deregulated c-Myc requires a functional HSF1 for experimental and human hepatocarcinogenesis
Cigliano, Pilo, Li et al
Oncotarget (2017) 8 (53), 90638-90650 DOI: 10.18632/oncotarget.21469
Cigliano, Pilo, Li et al
Oncotarget (2017) 8 (53), 90638-90650 DOI: 10.18632/oncotarget.21469
Cited by 39
AI Summary: OriGene products, specifically the HSF1 (Cat# SR311070) and c-Myc (Cat# SR304034) shRNA constructs, were used for gene silencing experiments to investigate the functional interplay between HSF1 and c-Myc in hepatocellular carcinoma models.
Deregulated c-Myc requires a functional HSF1 for experimental and human hepatocarcinogenesis
Cigliano, Pilo, Li et al
Oncotarget (2017) 8 (53), 90638-90650 DOI: 10.18632/oncotarget.21469
Cigliano, Pilo, Li et al
Oncotarget (2017) 8 (53), 90638-90650 DOI: 10.18632/oncotarget.21469
Snippet: tagged HSF1 (ID # RC200314) or untagged c-Myc (ID # SC112715) cDNA in pCMV6-Entry and pCMV6-XL5 plasmid (OriGene Technologies, Rockville, MD), respectively, were conducted in the MHCC97-L HCC cell line using the Lipofectamine 2000 Reagent (Life View as HTML;;Transient transfection experiments with DDK-tagged HSF1 (ID # RC200314) or untagged c-Myc (ID # SC112715) cDNA in pCMV6-Entry and pCMV6- XL5 plasmid (OriGene Technologies, Rockville, MD), respectively, were conducted in the MHCC97-L HCC cell line View as HTML;... Transient transfection experiments with DDK-tagged HSF1 (ID # RC200314) or untagged c-Myc (ID # SC112715) cDNA in pCMV6-Entry and pCMV6- XL5 plasmid (OriGene Technologies, Rockville, MD), respectively, were conducted in the MHCC97-L HCC cell line ... …
Cip2a promotes cell cycle progression in triple-negative breast cancer cells by regulating the expression and nuclear export of p27Kip1
Liu, Qiu, Song et al
Oncogene (2016)
Liu, Qiu, Song et al
Oncogene (2016)
AI Summary: OriGene products contributed to this study by providing the expression plasmids pCMV6-Cip2a, pCMV6-E2F1, pCMV6-c-myc, and the pCMV6-XL5 empty plasmid, which were used to manipulate gene expression in TNBC cells for functional analysis.
Snippet: Expression plasmid for pCMV6-Cip2a, pCMV6-E2F1, pCMV6-c-myc andpCMV6-XL5 empty plasmid was purchased from Origene (Rockville, MD, USA). All transfectionswere conducted using Lipofectamine 2000 according to the manufacturer's instructions (Invitrogen ... Cite SaveSaving
Showing 1-6 of 9 papers.
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