c-Myc (MYC) Mouse Monoclonal Antibody [Clone ID: OTI1A6]
$447.00
In Stock*
Specifications
| Product Data | |
| Clone Name | OTI1A6 |
|---|---|
| Application | FC, IF, IHC, WB |
| Recommended Dilution | WB 1:2000, IHC 1:50, IF 1:100, FLOW 1:100 |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Mouse |
| Isotype | IgG2b |
| Clonality | Monoclonal |
| Immunogen | Full length human recombinant protein of human Myc (NP_002458) produced in E.coli. |
| Buffer | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide |
| Concentration | 1 mg/ml |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 50.4 kDa |
| Gene Name | MYC proto-oncogene, bHLH transcription factor |
| Database Link | |
| Background | c-Myc is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. |
| Synonyms | bHLHe39; c-Myc; MRTL; MYCC |
| Reference Data | |
| Protein Categories | Cancer: Brain and CNS, Cancer: Gastrointestinal, Cancer: Gynecologic, Cancer: Haematopoietic and Lymphoid, Cancer: Head and Neck, Cancer: Lung, Cancer: Sarcoma, Cancer: Skin, Growth Factors, Intracellular Proteins, Transciption Factors |
| Protein Families | Druggable Genome, Embryonic stem cells, Induced pluripotent stem cells, Stem cell - Pluripotency, Stem cell relevant signaling - JAK/STAT signaling pathway, Stem cell relevant signaling - TGFb/BMP signaling pathway, Stem cell relevant signaling - Wnt Signaling pathway, Transcription Factors |
| Protein Pathways | Acute myeloid leukemia, Bladder cancer, Cell cycle, Chronic myeloid leukemia, Colorectal cancer, Endometrial cancer, ErbB signaling pathway, Jak-STAT signaling pathway, MAPK signaling pathway, Pathways in cancer, Small cell lung cancer, TGF-beta signaling pathway, Thyroid cancer, Wnt signaling pathway |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other "OTI1A6" antibodies (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| CF500002 | Carrier-free (BSA/glycerol-free) c-Myc mouse monoclonal antibody, clone OTI1A6 (formerly 1A6) | 100 ug |
$620.00
|
|
| TA500002AM | c-Myc mouse monoclonal antibody, clone 1A6, Biotinylated | 100 ul |
$509.00
|
|
| TA500002BM | c-Myc mouse monoclonal antibody, clone 1A6, HRP conjugated | 100 ul |
$509.00
|
|
| TA500002S | c-Myc (c-Myc ) mouse monoclonal antibody, clone OTI1A6 (formerly 1A6) | 30 ul |
$200.00
|
|
| TA600497 | purified MYC mouse monoclonal capture antibody, validated for ELISA and Luminex assays | 100 ug |
$458.00
|
|
| TA700496 | MYC biotinylated mouse monoclonal detection antibody, validated for ELISA and Luminex assays | 50 ug |
$494.00
|
|
Citations
Vasopressin-to-Oxytocin Receptor Crosstalk in the Preoptic Area Underlying Parental Behaviors in Male Mice
Inada, Hagihara, Yaguchi et al
bioRxiv (2024)
Inada, Hagihara, Yaguchi et al
bioRxiv (2024)
Cited by 2
Snippet: For the immunohistochemistry, the following reagents were used for primary antibodies: anti-GFP (GFP-1010;Aves Labs;1:500), anti-RFP (5f8;Chromotek;1:500), and anti-mCherry (AB0040-200;OriGene;1:500)
Optimizing rice grain size by attenuating phosphorylation-triggered functional impairment of a chromatin modifier ternary complex
Shen, Ma, Bai et al
Developmental Cell (2024) 59 (4), 448-464.e8 DOI: 10.1016/j.devcel.2023.12.013
Shen, Ma, Bai et al
Developmental Cell (2024) 59 (4), 448-464.e8 DOI: 10.1016/j.devcel.2023.12.013
Cited by 16
Control of grain size in rice by TGW3 phosphorylation of OsIAA10 through potentiation of OsIAA10-OsARF4-mediated auxin signaling
Ma, Shen, Bai et al
Cell Rep (2023) 42 (3), 112187 DOI: 10.1016/j.celrep.2023.112187
Ma, Shen, Bai et al
Cell Rep (2023) 42 (3), 112187 DOI: 10.1016/j.celrep.2023.112187
Cited by 48
AI Summary: OriGene’s Mouse monoclonal anti-c-Myc antibody (Cat# TA500002) was used in this study to detect c-Myc-tagged proteins, facilitating the analysis of protein interactions and modifications involved in auxin signaling and grain size regulation in rice.
Snippet: Mouse monoclonal anti-c-Myc ORIGENE Cat#TA500002
Microglial TREM2 Mitigates Inflammatory Responses and Neuronal Apoptosis in Angiotensin II-Induced Hypertension in Middle-Aged Mice
Xu, Du, Jiang et al
Front Aging Neurosci (2021) 13, 716917 DOI: 10.3389/fnagi.2021.716917
Xu, Du, Jiang et al
Front Aging Neurosci (2021) 13, 716917 DOI: 10.3389/fnagi.2021.716917
Cited by 24
AI Summary: In this paper, OriGene’s TREM2 overexpression plasmid (Cat# MR227768) was used to investigate the role of microglial TREM2 in mitigating inflammatory responses and neuronal apoptosis in angiotensin II-induced hypertension in mice.
Showing 1-4 of 4 papers.
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