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c-Myc (MYC) (NM_002467) Human Tagged ORF Clone Lentiviral Particle

  • LentiORF®
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RC201611L3V
Lenti ORF particles, MYC (Myc-DDK tagged) - Human v-myc myelocytomatosis viral oncogene homolog (avian) (MYC), 200ul, >10^7 TU/mL
file-pdf Biosafety Sheet
ORF Plasmid:
DDK tGFP
Lentiviral Particles:
DDK w/ Puro DDK mGFP mGFP w/ Puro
  $1,236.00
2 Weeks*
Bulk Requests & Clone Modifications

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Other products for "c-Myc or NM_002467"

Specifications
Specifications
Product Data
Type Human Tagged ORF Clone Lentiviral Particle
Tag Myc-DDK
Target Symbol c-Myc
Synonyms bHLHe39; c-Myc; MRTL; MYCC
Vector pLenti-C-Myc-DDK-P2A-Puro
Mammalian Cell Selection Puromycin
Sequence Data
ORF Nucleotide Sequence
The ORF insert of this clone is exactly the same as(RC201611).
ACCN NM_002467
ORF Size 1362 bp
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Shipping Dry Ice
Reference Data
RefSeq NM_002467.3
RefSeq Size 2379 bp
RefSeq ORF 1365 bp
Locus ID 4609
UniProt ID P01106
Cytogenetics 8q24.21
Domains HLH, Myc-LZ, Myc_N_term
Protein Families Druggable Genome, Embryonic stem cells, Induced pluripotent stem cells, Stem cell - Pluripotency, Stem cell relevant signaling - JAK/STAT signaling pathway, Stem cell relevant signaling - TGFb/BMP signaling pathway, Stem cell relevant signaling - Wnt Signaling pathway, Transcription Factors
Protein Pathways Acute myeloid leukemia, Bladder cancer, Cell cycle, Chronic myeloid leukemia, Colorectal cancer, Endometrial cancer, ErbB signaling pathway, Jak-STAT signaling pathway, MAPK signaling pathway, Pathways in cancer, Small cell lung cancer, TGF-beta signaling pathway, Thyroid cancer, Wnt signaling pathway
MW 50.5 kDa
Summary This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini. provided by RefSeq, Aug 2017
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Documents
Resources

file-alt Citations

A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo
Bai, Zhou, Xu et al
Cancer Cell (2019) 36 (5), 498-511.e17 DOI: 10.1016/j.ccell.2019.10.002
Cited by 637
AI Summary: OriGene products, specifically LentiORF control particles (PS100092V) and Lenti ORF particles expressing MYC (RC201611L1V and RC201611L3V), were used in this study to manipulate gene expression in cell models, enabling the evaluation of STAT3 degradation and its effects on cancer cells.
Snippet: STAT3 Firefly luciferase reporter lentivirus (Puro) Cellomics Technology PLV-10065-50 LentiORF control particles OriGene Technologies PS100092V Lenti ORF particles, MYC (Myc-DDK tagged) OriGene Technologies RC201611L1V Lenti ORF particles, MYC (Myc-DDK tagged) OriGene Technologies RC201611L3V SMARTvector Human Lentiviral CRBN shRNA Dharmacon V3SH7596
Figure
Showing 1-1 of 1 papers.
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