NLRP3 (NM_004895) Human Recombinant Protein
SKU
TP320952
Purified recombinant protein of Human NLR family, pyrin domain containing 3 (NLRP3), transcript variant 1, full length, with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20 µg
$867.00
In Stock*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | Myc-DDK |
| Predicted MW | 118 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_004886 |
| Locus ID | 114548 |
| UniProt ID | Q96P20 |
| Cytogenetics | 1q44 |
| RefSeq Size | 4484 |
| RefSeq ORF | 3108 |
| Synonyms | AGTAVPRL; AII; AVP; C1orf7; CIAS1; CLR1.1; DFNA34; FCAS; FCAS1; FCU; KEFH; MWS; NALP3; PYPAF1 |
| Summary | This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NLRP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. The SARS-CoV 3a protein, a transmembrane pore-forming viroporin, has been shown to activate the NLRP3 inflammasome via the formation of ion channels in macrophages. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, neonatal-onset multisystem inflammatory disease (NOMID), keratoendotheliitis fugax hereditarian, and deafness, autosomal dominant 34, with or without inflammation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid. provided by RefSeq, Aug 2020 |
| Protein Categories | Allergies and autoimmune diseases, Cytokines, Intracellular Proteins, Nervous system Diseases |
| Protein Families | Druggable Genome |
| Protein Pathways | NOD-like receptor signaling pathway |
Reviews
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| FAQs |
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Resources
| Recombinant Protein Resources |
Other "NLRP3" proteins (8)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| LC401526 | Lyophilized NLRP3 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LC421550 | Lyophilized NLRP3 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LC426795 | Lyophilized NLRP3 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY401526 | Transient overexpression lysate of NLR family, pyrin domain containing 3 (NLRP3), transcript variant 1 (as WB positive control) | 100 ug |
$665.00
|
|
| LY421550 | Transient overexpression lysate of NLR family, pyrin domain containing 3 (NLRP3), transcript variant 3 (as WB positive control) | 100 ug |
$665.00
|
|
| LY426795 | Transient overexpression lysate of NLR family, pyrin domain containing 3 (NLRP3), transcript variant 4 (as WB positive control) | 100 ug |
$665.00
|
|
| TP750176 | Purified recombinant protein of Human NLR family, pyrin domain containing 3 (NLRP3), transcript variant 3, full length, with C-terminal HIS tag, expressed in E.Coli, 50 ug | 50 ug |
$270.00
|
|
| TP762656 | Purified recombinant protein of Human NLR family, pyrin domain containing 3 (NLRP3), transcript variant 4, full length, with N-GST and C-His tag, expressed in E.coli, 50ug | 50 ug |
$270.00
|
|
Citations
Cofilin-1 is a redox-sensitive guard of the NLRP3 inflammasome
Park, Batu, Matthiasardottir et al
Nat Immunol (2026)
Park, Batu, Matthiasardottir et al
Nat Immunol (2026)
Cited by 5
AI Summary: OriGene contributed to this study by providing recombinant human NLRP3 protein (TP320952), which was used to investigate the interaction between NLRP3 and cofilin-1 in the regulation of inflammasome activation.
Snippet: were obtained from InvivoGen. Luteolin (2874), MCC950 (5479) and KH7 (3834) were from Tocris Bioscience. Recombinant human NLRP3 protein (TP320952) was from Origene, and recombinant human cofilin-1 protein (CF01) was from Cytoskeleton
Cofilin-1 is a Redox-Sensitive Guard of the NLRP3 Inflammasome
Chae, Park, Kim et al
Research Square (2025)
Chae, Park, Kim et al
Research Square (2025)
AI Summary: OriGene’s recombinant human NLRP3 protein (catalog number TP320952) was used in this study to investigate the molecular interactions between NLRP3 and cofilin-1, supporting the discovery of cofilin-1 as a redox-sensitive regulator of the NLRP3 inflammasome.
Snippet: rl-msu), and ultra-pure LPS (tlrl-3pelps) were obtained from InvivoGen. Luteolin (2874), MCC950 (5479), and KH7 (3834) were from Tocris Bioscience. Recombinant human NLRP3 protein (TP320952) was from Origene and recombinant human Cofilin-1 protein (CF01) was from Cytoskeleton. MICE We used 8- to 16-week-old male and female mice (_Mus musculus_) on a C57BL/6J background in our experiments. Wild-t
A cis-regulatory element controls expression of histone deacetylase 9 to fine-tune inflammasome-dependent chronic inflammation in atherosclerosis
Asare, Yan, Schlegl et al
Immunity (2025)
Asare, Yan, Schlegl et al
Immunity (2025)
Cited by 34
Showing 1-3 of 3 papers.
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