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NLRP3 (NM_001127461) Human Recombinant Protein

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SKU
TP762656
Purified recombinant protein of Human NLR family, pyrin domain containing 3 (NLRP3), transcript variant 4, full length, with N-GST and C-His tag, expressed in E.coli, 50ug
Size:
50 ug
  $270.00
4 Weeks*
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Specifications
Specifications
Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
Protein Sequence
A DNA sequence encoding the region full length of NLRP3
Tag N-GST and C-HIS
Predicted MW 140.2kDa
Concentration >0.05 µg/µL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 50 mM Tris-HCl, pH 8.0, 8 M urea
Note For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage Store at -80°C after receiving vials.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Shipping Dry Ice
Reference Data
RefSeq NP_001120933
Locus ID 114548
UniProt ID Q96P20
Cytogenetics 1q44
RefSeq ORF 2937
Synonyms AGTAVPRL; AII; AVP; C1orf7; CIAS1; CLR1.1; DFNA34; FCAS; FCAS1; FCU; KEFH; MWS; NALP3; PYPAF1
Summary This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NLRP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. The SARS-CoV 3a protein, a transmembrane pore-forming viroporin, has been shown to activate the NLRP3 inflammasome via the formation of ion channels in macrophages. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, neonatal-onset multisystem inflammatory disease (NOMID), keratoendotheliitis fugax hereditarian, and deafness, autosomal dominant 34, with or without inflammation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid. provided by RefSeq, Aug 2020
Protein Categories Allergies and autoimmune diseases, Cytokines, Intracellular Proteins, Nervous system Diseases
Protein Families Druggable Genome
Protein Pathways NOD-like receptor signaling pathway
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Other "NLRP3" proteins (8)
SKU Description Size Price
LC401526 Lyophilized NLRP3 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LC421550 Lyophilized NLRP3 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LC426795 Lyophilized NLRP3 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY401526 Transient overexpression lysate of NLR family, pyrin domain containing 3 (NLRP3), transcript variant 1 (as WB positive control) 100 ug
$665.00
LY421550 Transient overexpression lysate of NLR family, pyrin domain containing 3 (NLRP3), transcript variant 3 (as WB positive control) 100 ug
$665.00
LY426795 Transient overexpression lysate of NLR family, pyrin domain containing 3 (NLRP3), transcript variant 4 (as WB positive control) 100 ug
$665.00
TP320952 Purified recombinant protein of Human NLR family, pyrin domain containing 3 (NLRP3), transcript variant 1, full length, with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20 µg 20 ug
$867.00
TP750176 Purified recombinant protein of Human NLR family, pyrin domain containing 3 (NLRP3), transcript variant 3, full length, with C-terminal HIS tag, expressed in E.Coli, 50 ug 50 ug
$270.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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