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MITF (NM_000248) Human Recombinant Protein

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SKU
TP761494
Purified recombinant protein of Human microphthalmia-associated transcription factor (MITF), transcript variant 4, full length, with N-terminal HIS tag, expressed in E.coli, 50ug
Size:
50 ug
  $270.00
In Stock*
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Frequently Bought Together (1)

TA314196 Rabbit polyclonal MITF (Ab-180/73) antibody
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Other products for "MITF or NM_000248"

Specifications
Specifications
Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
Protein Sequence
A DNA sequence encoding human full-length MITF
Tag N-His
Predicted MW 46.8 kDa
Concentration >0.05 µg/µL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris-HCl, pH 8.0, 150 mM NaCl, 1% sarkosyl, 10% glycerol
Note For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Shipping Dry Ice
Reference Data
RefSeq NP_000239
Locus ID 4286
UniProt ID O75030
Cytogenetics 3p13
RefSeq Size 4490
RefSeq ORF 1257
Synonyms bHLHe32; CMM8; COMMAD; MI; WS2; WS2A
Summary The protein encoded by this gene is a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. The encoded protein regulates melanocyte development and is responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. provided by RefSeq, Aug 2017
Protein Categories Cancer: Skin, Intracellular Proteins, Transciption Factors
Protein Families Druggable Genome, Transcription Factors
Protein Pathways Melanogenesis, Melanoma, Pathways in cancer
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Other "MITF" proteins (5)
SKU Description Size Price
LC404984 Lyophilized MITF HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LC424990 Lyophilized MITF HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY404984 Transient overexpression lysate of microphthalmia-associated transcription factor (MITF), transcript variant 6 (as WB positive control) 100 ug
$665.00
LY424990 Transient overexpression lysate of microphthalmia-associated transcription factor (MITF), transcript variant 4 (as WB positive control) 100 ug
$436.00
TP761396 Purified recombinant protein of Human microphthalmia-associated transcription factor (MITF), transcript variant 5, full length, with N-terminal GST and C-terminal HIS tag, expressed in E. coli, 50ug 50 ug
$270.00

file-alt Citations

A Basic Domain-Derived Tripeptide Inhibits MITF Activity by Reducing its Binding to the Promoter of Target Genes
Lim, Lee, Kim et al
J Invest Dermatol (2021)
Cited by 14
AI Summary: OriGene’s recombinant human MITF protein was used to assess the binding kinetics and affinities of the MITF-KGR tripeptide, demonstrating its ability to disrupt MITF’s interaction with DNA and inhibit melanogenesis.
Snippet: Binding kinetics and affinities of MITF-KGR to recombinant human MITF (OriGene, Rockville, MD) were assessed using a ProteOnXPR36 (Bio-Rad Laboratories, Hercules, CA). The GLH sensor chip (Bio-Rad Laboratories) was activated with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride and N-hydroxysulfosuccinimide according to the manufacturer’s instructions
Showing 1-1 of 1 papers.
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