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SIRP alpha (SIRPA) Human Recombinant Protein

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SKU
TP723932
Recombinant Human SIRPa with C-terminal human Fc and 6×His tag
Size:
100 ug
  $795.00
4 Weeks*
Bulk/Customize

Frequently Bought Together (1)

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Specifications
Specifications
Product Data
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence
Protein Sequence
SIRPa(Glu31-Tyr373) hFc(Glu99-Ala330) 6×His tag
Tag C-Human Fc and 6×His Tag
Predicted MW The protein has a predicted molecular mass of 70-98 kDa after removal of the signal peptide.
Purity The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Buffer Lyophilized from sterile PBS, pH 7.4. Normally 5% - 8% trehalose is added as protectants before lyophilization
Reconstitution Method 1. Before opening the tube cap, centrifuge the sample tube at 5000g for 3-5min at room temperature to ensure the lyophilized sample settles down at the bottom of the tube.
2. Calculate the volume for reconstitution (in µL) using the formula: Quantity (mg)/Concentration (mg/mL)x1000
3. Dissolve the lyophilized protein sample in sterile water based on the calculated volume (µL)
4. After adding sterile water, cover the lid and mix by gently tapping the tube 5-10 times. Note: Do not vortex or vigorously pipette the sample.
Preparation Affinity purification
Recommended Dilution ELISA
Storage Store the lyophilized protein at -20°C.
After reconstitution, store the protein at -80°C for 12 months.
Avoid repeated freezing and thawing.
Stability 12 months from date of despatch
Shipping Ambient
Reference Data
Locus ID 140885
UniProt ID P78324
Synonyms SHPS1;SIRPA;CD172A;BIT;MFR;MYD1;P84;PTPNS
Summary Tyrosine-protein phosphatase non-receptor type substrate 1 (SHPS1) is also known as CD172 antigen-like family member A (CD172a), Macrophage fusion receptor, MyD-1 antigen, Signal-regulatory protein alpha (SIRPA or SIRP alpha) or p84, is a member of the SIRP family, and also belongs to the immunoglobulin superfamily. SIRP alpha is Ubiquitous and highly expressed in brain. SIRPA / CD172a is immunoglobulin-like cell surface receptor for CD47 and acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA / SHPS-1 supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment and may play a key role in intracellular signaling during synaptogenesis and in synaptic function By similarity. SIRPA / MyD1 involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin and mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.
Protein Categories CD Markers, Chemokines, Cytokines, Growth Factors, Membrane Proteins
Protein Families ELISA
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Other "SIRP alpha" proteins (13)
SKU Description Size Price
PH307315 SIRPA MS Standard C13 and N15-labeled recombinant protein (NP_542970) 10 ug
$3,360.00
PH316320 SIRPA MS Standard C13 and N15-labeled recombinant protein (NP_001035112) 10 ug
$3,360.00
PH322380 SIRPA MS Standard C13 and N15-labeled recombinant protein (NP_001035111) 10 ug
$3,360.00
LC409074 Lyophilized SIRPA HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LC421878 Lyophilized SIRPA HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LC421879 Lyophilized SIRPA HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY409074 Transient overexpression lysate of signal-regulatory protein alpha (SIRPA), transcript variant 3 (as WB positive control) 100 ug
$436.00
LY421878 Transient overexpression lysate of signal-regulatory protein alpha (SIRPA), transcript variant 1 (as WB positive control) 100 ug
$665.00
LY421879 Transient overexpression lysate of signal-regulatory protein alpha (SIRPA), transcript variant 2 (as WB positive control) 100 ug
$665.00
TP307315 Recombinant protein of human signal-regulatory protein alpha (SIRPA), transcript variant 3, 20 µg 20 ug
$737.00
TP316320 Recombinant protein of human signal-regulatory protein alpha (SIRPA), transcript variant 2, 20 µg 20 ug
$737.00
TP322380 Recombinant protein of human signal-regulatory protein alpha (SIRPA), transcript variant 1, 20 µg 20 ug
$737.00
TP762372 Purified recombinant protein of Human signal-regulatory protein alpha (SIRPA), transcript variant 1, Glu31-Ile373, with N-terminal His tag, expressed in E.coli, 50ug 50 ug
$260.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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