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FLT3 Human Recombinant Protein

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SKU
TP723930
Recombinant human FLT3 protein with C-terminal human Fc and 6×His tag
Size:
100 ug
  $795.00
4 Weeks*
Bulk/Customize

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Specifications
Specifications
Product Data
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence
Protein Sequence
FLT3(Asn27-Ser543) hFc(Glu99-Ala330) 6×His tag
Tag C-Human Fc and 6×His Tag
Predicted MW The protein has a predicted molecular mass of 125-130 kDa after removal of the signal peptide.
Purity The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Buffer Lyophilized from sterile PBS, pH 7.4. Normally 5% - 8% trehalose is added as protectants before lyophilization
Reconstitution Method 1. Before opening the tube cap, centrifuge the sample tube at 5000g for 3-5min at room temperature to ensure the lyophilized sample settles down at the bottom of the tube.
2. Calculate the volume for reconstitution (in µL) using the formula: Quantity (mg)/Concentration (mg/mL)x1000
3. Dissolve the lyophilized protein sample in sterile water based on the calculated volume (µL)
4. After adding sterile water, cover the lid and mix by gently tapping the tube 5-10 times. Note: Do not vortex or vigorously pipette the sample.
Preparation Affinity purification
Recommended Dilution ELISA
Storage Store the lyophilized protein at -20°C.
After reconstitution, store the protein at -80°C for 12 months.
Avoid repeated freezing and thawing.
Stability 12 months from date of despatch
Shipping Ambient
Reference Data
Locus ID 2322
UniProt ID P36888
Synonyms Flt-3;Flk-2;STK-1;CD135;FLK2;FLT-3
Summary Flt-3(Receptor-type tyrosine-protein kinase FLT3) is also known as FLK-2(Fetal liver kinase-2), STK-1(Stem cell tyrosine kinase 1), CD135. FLT3 is a cytokine receptor which belongs to the receptor tyrosine kinase class III. Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.
Protein Categories Cancer: Haematopoietic and Lymphoid, CD Markers, Cytokines, Enzyme: Kinases, Growth Factors, Membrane Proteins
Protein Families ELISA
Protein Pathways Acute myeloid leukemia, Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Pathways in cancer
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Documents
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Other "FLT3" proteins (6)
SKU Description Size Price
PH311459 FLT3 MS Standard C13 and N15-labeled recombinant protein (NP_004110) 10 ug
$3,360.00
LC418194 Lyophilized FLT3 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY418194 Transient overexpression lysate of fms-related tyrosine kinase 3 (FLT3) (as WB positive control) 100 ug
$665.00
TP311459 Recombinant protein of human fms-related tyrosine kinase 3 (FLT3), 20 µg 20 ug
$867.00
TP700113 Recombinant protein of human fms-related tyrosine kinase 3 (FLT3), with C-terminal DDK/His tag, expressed in human cells, 20 µg 20 ug
$900.00
TP710100 Recombinant protein of human fms-related tyrosine kinase 3 (FLT3), residues 27-543aa, with C-terminal DDK tag, expressed in sf9, 20ug 20 ug
$540.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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