FLT3 (NM_004119) Human Mass Spec Standard
$3,360.00
3 Weeks*
Specifications
| Product Data | |
| Tag | C-Myc/DDK |
|---|---|
| Species | Human |
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | RC211459 |
| Predicted MW | 112.7 kDa |
| Protein Sequence | |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Labeling Method | Labeled with U- 13C6, 15N4-L-Arginine and U- 13C6, 15N2-L-Lysine |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3 |
| Storage | Store at -80°C. Avoid repeated freeze-thaw cycles. |
| Stability | Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_004110 |
| RefSeq Size | 3475 |
| RefSeq ORF | 2979 |
| Synonyms | CD135; FLK-2; FLK2; STK1 |
| Locus ID | 2322 |
| UniProt ID | P36888 |
| Cytogenetics | 13q12.2 |
| Summary | This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. provided by RefSeq, Jan 2015 |
| Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase, Transmembrane |
| Protein Pathways | Acute myeloid leukemia, Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Pathways in cancer |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "FLT3" proteins (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| LC418194 | Lyophilized FLT3 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY418194 | Transient overexpression lysate of fms-related tyrosine kinase 3 (FLT3) (as WB positive control) | 100 ug |
$665.00
|
|
| TP311459 | Recombinant protein of human fms-related tyrosine kinase 3 (FLT3), 20 µg | 20 ug |
$867.00
|
|
| TP700113 | Recombinant protein of human fms-related tyrosine kinase 3 (FLT3), with C-terminal DDK/His tag, expressed in human cells, 20 µg | 20 ug |
$900.00
|
|
| TP710100 | Recombinant protein of human fms-related tyrosine kinase 3 (FLT3), residues 27-543aa, with C-terminal DDK tag, expressed in sf9, 20ug | 20 ug |
$540.00
|
|
| TP723930 | Recombinant human FLT3 protein with C-terminal human Fc and 6×His tag | 100 ug |
$795.00
|
|
Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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