FLT3 (NM_004119) Human Recombinant Protein
$867.00
In Stock*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 112.7 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_004110 |
| Locus ID | 2322 |
| UniProt ID | P36888 |
| Cytogenetics | 13q12.2 |
| RefSeq Size | 3475 |
| RefSeq ORF | 2979 |
| Synonyms | CD135; FLK-2; FLK2; STK1 |
| Summary | This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. provided by RefSeq, Jan 2015 |
| Protein Categories | Cancer: Haematopoietic and Lymphoid, CD Markers, Cytokines, Enzyme: Kinases, Growth Factors, Membrane Proteins |
| Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase, Transmembrane |
| Protein Pathways | Acute myeloid leukemia, Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Pathways in cancer |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "FLT3" proteins (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| PH311459 | FLT3 MS Standard C13 and N15-labeled recombinant protein (NP_004110) | 10 ug |
$3,360.00
|
|
| LC418194 | Lyophilized FLT3 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY418194 | Transient overexpression lysate of fms-related tyrosine kinase 3 (FLT3) (as WB positive control) | 100 ug |
$665.00
|
|
| TP700113 | Recombinant protein of human fms-related tyrosine kinase 3 (FLT3), with C-terminal DDK/His tag, expressed in human cells, 20 µg | 20 ug |
$900.00
|
|
| TP710100 | Recombinant protein of human fms-related tyrosine kinase 3 (FLT3), residues 27-543aa, with C-terminal DDK tag, expressed in sf9, 20ug | 20 ug |
$540.00
|
|
| TP723930 | Recombinant human FLT3 protein with C-terminal human Fc and 6×His tag | 100 ug |
$795.00
|
|
Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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