FLT3 Mouse Monoclonal Antibody [Clone ID: OTI7D6]
$447.00
In Stock*
Specifications
| Product Data | |
| Clone Name | OTI7D6 |
|---|---|
| Application | WB |
| Recommended Dilution | WB 1:500 |
| Reactivity | Human, Mouse |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 169-444 of human FLT3(NP_004110) produced in E.coli. |
| Buffer | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide |
| Concentration | 1 mg/ml |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 112.7 kDa |
| Gene Name | fms related tyrosine kinase 3 |
| Database Link | |
| Background | This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. provided by RefSeq, Jul 2008 |
| Synonyms | CD135; FLK-2; FLK2; STK1 |
| Reference Data | |
| Protein Categories | Cancer: Haematopoietic and Lymphoid, CD Markers, Cytokines, Enzyme: Kinases, Growth Factors, Membrane Proteins |
| Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase, Transmembrane |
| Protein Pathways | Acute myeloid leukemia, Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Pathways in cancer |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other "OTI7D6" antibodies (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| CF808157 | Carrier-free (BSA/glycerol-free) FLT3 mouse monoclonal antibody, clone OTI7D6 (formerly 7D6) | 100 ug |
$620.00
|
|
| TA808157AM | FLT3 mouse monoclonal antibody, clone OTI7D6 (formerly 7D6), Biotinylated | 100 ul |
$509.00
|
|
| TA808157BM | FLT3 mouse monoclonal antibody, clone OTI7D6 (formerly 7D6), HRP conjugated | 100 ul |
$509.00
|
|
| TA808157S | FLT3 mouse monoclonal antibody, clone OTI7D6 (formerly 7D6) | 30 ul |
$200.00
|
|
Citations
Epitope editing enables targeted immunotherapy of acute myeloid leukaemia
Casirati, Cosentino, Mucci et al
Nature (2023) 621 (7978), 404-414 DOI: 10.1038/s41586-023-06496-5
Casirati, Cosentino, Mucci et al
Nature (2023) 621 (7978), 404-414 DOI: 10.1038/s41586-023-06496-5
Cited by 116
AI Summary: In this study, the OriGene anti-FLT3 antibody (TA808157) was used to detect FLT3 protein expression in immunoblot analyses, helping to assess the effectiveness of epitope editing in conferring resistance to targeted immunotherapies in acute myeloid leukaemia.
Snippet: ibodies, the membranes were incubated for 30 min with Thermo Scientific Restore Stripping Buffer (Thermo Fisher Scientific, 21059), blocked, washed and incubated with primary antibodies (anti-FLT3, Origene, TA808157;anti-KIT, Invitrogenc MA5-15894). The membrane was then washed and incubated with secondary antibodies (anti-mouse IgG, HRP-linked antibodies, Thermo Fisher Scientific, 62-6520;or;blocked, washed and incubated with primary antibodies (anti-FLT3, Origene, TA808157;anti-KIT, Invitrogenc MA5-15894)
Showing 1-1 of 1 papers.
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