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Thymidylate Synthase (TYMS) (NM_001071) Human Recombinant Protein

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SKU
TP710029
Recombinant protein of human thymidylate synthetase (TYMS), full length, with N-terminal polyhistidine tag, expressed in sf9 cells.
Size:
20 ug
  $540.00
In Stock*
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Frequently Bought Together (1)

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Specifications
Specifications
Product Data
Species Human
Expression Host Sf9
Expression cDNA Clone or AA Sequence
Protein Sequence
A DNA sequence from TrueORF clone, RC204814, encoding human full-length TYMS
Tag N-His
Predicted MW 36 kDa
Concentration >0.05 µg/µL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 50 mM Tris-HCl, pH 8.0, 150 mM NaCl, 10% glycerol
Note For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Shipping Dry Ice
Reference Data
RefSeq NP_001062
Locus ID 7298
UniProt ID P04818
Cytogenetics 18p11.32
RefSeq Size 1536
RefSeq ORF 939
Synonyms HST422; TMS; TS
Summary Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy. provided by RefSeq, Aug 2017
Protein Categories Cytokines, Growth Factors, Intracellular Proteins
Protein Families Druggable Genome
Protein Pathways Metabolic pathways, One carbon pool by folate, Pyrimidine metabolism
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Other "Thymidylate Synthase" proteins (4)
SKU Description Size Price
PH304814 TYMS MS Standard C13 and N15-labeled recombinant protein (NP_001062) 10 ug
$3,360.00
LC420700 Lyophilized TYMS HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY420700 Transient overexpression lysate of thymidylate synthetase (TYMS) (as WB positive control) 100 ug
$436.00
TP304814 Recombinant protein of human thymidylate synthetase (TYMS), 20 µg 20 ug
$737.00

file-alt Citations

Synthesis of N5-furoxan-functionalized pyrazolo[3,4-d]pyrimidinones as novel nonclassical DHFR/TS inhibitors with potential apoptotic and anti-migratory activity
Alotaibi, Abou-Salim
Bioorg Chem (2026) 181, 110269 DOI: 10.1016/j.bioorg.2026.110269
AI Summary: OriGene's hTS kit (Cat. No. TP710029) was used in this study to evaluate the inhibitory effects of the synthesized compounds on thymidylate synthase levels in vitro.
Snippet: The in vitro inhibitory effect of the test analogs on thymidylate synthase (TS) levels was evaluated using a hTS ELISA kit (Cat. No. MBS261554, MyBioSource, San Diego, CA, USA) and hTS kit (Cat. No. TP710029, OriGene Technologies, Rockville, MD, USA)
Showing 1-1 of 1 papers.
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