EMA (MUC1) (NM_001018016) Human Recombinant Protein
SKU
TP321390
Recombinant protein of human mucin 1, cell surface associated (MUC1), transcript variant 2, 20 µg
$737.00
5 Days*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 25.1 kDa |
| Concentration | >0.1 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Bioactivity | ELISA capture for autoantibodies (PMID: 26960182) |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_001018016 |
| Locus ID | 4582 |
| UniProt ID | P15941 |
| Cytogenetics | 1q22 |
| RefSeq Size | 1193 |
| RefSeq ORF | 792 |
| Synonyms | ADMCKD; ADMCKD1; ADTKD2; CA 15-3; CD227; EMA; H23AG; KL-6; MAM6; MCD; MCKD; MCKD1; MUC-1; MUC-1/SEC; MUC-1/X; MUC1/ZD; PEM; PEMT; PUM |
| Summary | This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.provided by RefSeq, Feb 2011 |
| Protein Categories | ADC Targets, CAR-T Targets, CD Markers, Intracellular Proteins, Membrane Proteins, Secreated Proteins |
| Protein Families | Druggable Genome, Secreted Protein, Transmembrane |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "EMA" proteins (10)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| PH321390 | MUC1 MS Standard C13 and N15-labeled recombinant protein (NP_001018016) | 10 ug |
$3,360.00
|
|
| LC400880 | Lyophilized MUC1 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LC420828 | Lyophilized MUC1 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LC422694 | Lyophilized MUC1 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LC422695 | Lyophilized MUC1 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY400880 | Transient overexpression lysate of mucin 1, cell surface associated (MUC1), transcript variant 1 (as WB positive control) | 100 ug |
$436.00
|
|
| LY420828 | Transient overexpression lysate of mucin 1, cell surface associated (MUC1), transcript variant 6 (as WB positive control) | 100 ug |
$436.00
|
|
| LY422694 | Transient overexpression lysate of mucin 1, cell surface associated (MUC1), transcript variant 2 (as WB positive control) | 100 ug |
$436.00
|
|
| LY422695 | Transient overexpression lysate of mucin 1, cell surface associated (MUC1), transcript variant 3 (as WB positive control) | 100 ug |
$436.00
|
|
| TP760771 | Purified recombinant protein of Human mucin 1, cell surface associated (MUC1), transcript variant 3, full length, with N-terminal HIS tag, expressed in E. coli, 50ug | 50 ug |
$270.00
|
|
Citations
A large-area organic transistor with 3D-printed sensing gate for noninvasive single-molecule detection of pancreatic mucinous cyst markers
Sarcina, Viola, Modena et al
Anal Bioanal Chem (2022) 414 (18), 5657-5669 DOI: 10.1007/s00216-022-04040-4
Sarcina, Viola, Modena et al
Anal Bioanal Chem (2022) 414 (18), 5657-5669 DOI: 10.1007/s00216-022-04040-4
Cited by 20
AI Summary: OriGene contributed the anti-MUC1 antibody (clone UMAB57, code: UM800008) and recombinant human MUC1 protein (product number: TP321390) used as key reagents for functionalizing the biosensor and validating single-molecule detection of pancreatic mucinous cyst markers in this study.
Snippet: UC1, clone UMAB57, code: UM800008) and the recombinant protein of human mucin 1, cell surface-associated (MUC1), transcript variant 2 (MUC1, MW = 25,100 Da, product number: TP321390) were provided by OriGene. 3-Mercaptopropionic acid (3-MPA), 11-mercaptoundecanoic acid (11-MUA), 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) and the N-hydroxysulfosuccinimide sodium salt (Sulfo-NHS) were obta;cell surface-associated (MUC1), transcript variant 2 (MUC1, MW = 25,100 Da, product number: TP321390) were provided by OriGene. 3-Mercaptopropionic acid (3-MPA), 11-mercaptoundecanoic acid (11-MUA), 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) and the N-hydroxysulfosuccinimide sodium salt (Sulfo-NHS) were obtained from Merck Millipore
Single‐Molecule Bioelectronic Label‐Free Assay of both Protein and Genomic Markers of Pancreatic Mucinous Cysts’ in Whole Blood Serum
Macchia, Sarcina, Driescher et al
Adv. Electron. Mater. (2021)
Macchia, Sarcina, Driescher et al
Adv. Electron. Mater. (2021)
Cited by 31
Enhanced binding of antibodies generated during chronic HIV infection to mucus component MUC16
Gunn, Schneider, Shansab et al
Mucosal Immunol (2016) 9 (6), 1549-1558 DOI: 10.1038/mi.2016.8
Gunn, Schneider, Shansab et al
Mucosal Immunol (2016) 9 (6), 1549-1558 DOI: 10.1038/mi.2016.8
Cited by 52
AI Summary: OriGene's recombinant MUC1 protein (aa1-264) was used as an immobilized antigen in ELISA assays to assess antibody binding, contributing to the study's analysis of antibody interactions with mucin components during chronic HIV infection.
Snippet: Recombinant galectins (R&D Systems), MUC1 (aa1-264;Origene), MUC16 (aa21005-21992;R&D Systems), or native MUC16 isolated from OVCAR3 cells (see SM for details) were immobilized onto ELISA plates, and Abs were assayed for binding using detecting using α-human IgG Fc (MP Cappel)
Showing 1-3 of 3 papers.
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complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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