RFX5 (NM_001025603) Human Recombinant Protein

CAT#: TP312448

Recombinant protein of human regulatory factor X, 5 (influences HLA class II expression) (RFX5), transcript variant 2

 Product Datasheet for 'TP312448'

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USD 748.00

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    • 20 ug

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Product Data
Description Recombinant protein of human regulatory factor X, 5 (influences HLA class II expression) (RFX5), transcript variant 2
Species Human
Expression Host HEK293T
Expression cDNA Clone or AA Sequence Recombinant protein was produced with TrueORF clone, RC212448. Click on the TrueORF clone link to view cDNA and protein sequences.
Predicted MW 65.1 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. Store at –80C. Avoid repeated freeze-thaw cycles. Stable for 3 months from receipt of products under proper storage and handling conditions.
Reference Data
RefSeq NP_001020774
Locus ID 5993
Refseq Size 3611
Cytogenetics 1q21.3
Refseq ORF 1848
Synonyms regulatory factor X, 5 (influences HLA class II expression); OTTHUMP00000082795; OTTHUMP00000196318; regulatory factor X, 5
Summary A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency, or the bare lymphocyte syndrome (BLS; MIM 209920). At least 4 complementation groups have been identified in B-cell lines established from patients with BLS. The molecular defects in complementation groups B, C, and D all lead to a deficiency in RFX, a nuclear protein complex that binds to the X box of MHC-II promoters. The lack of RFX binding activity in complementation group C results from mutations in the RFX5 gene encoding the 75-kD subunit of RFX (Steimle et al., 1995). RFX5 is the fifth member of the growing family of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain called the RFX motif. Multiple alternatively spliced transcript variants have been found but the full-length natures of only two have been determined. [provided by RefSeq, Jul 2008].
Protein Families Transcription Factors
Protein Pathways Antigen processing and presentation, Primary immunodeficiency


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