Amyloid Precursor Protein (APP) (NM_201413) Human Recombinant Protein

CAT#: TP309575

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Recombinant protein of human amyloid beta (A4) precursor protein (APP), transcript variant 2


 Product Datasheet for 'TP309575'

 Cited in 2 publications.

  View other "APP" proteins (13)

USD 748.00


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Size
    • 20 ug


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Specifications

Product Data
Description Recombinant protein of human amyloid beta (A4) precursor protein (APP), transcript variant 2
Species Human
Expression Host HEK293T
Tag C-Myc/DDK
Predicted MW 83 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Bioactivity Enzyme substrate (PMID: 25724648)
Preparation Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Reference Data
RefSeq NP_958816
Locus ID 351
Refseq Size 3584
Cytogenetics 21q21.3
Refseq ORF 2253
Synonyms AAA; ABETA; ABPP; AD1; APPI; CTFgamma; CVAP; PN-II; PN2
Summary This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014]
Protein Families Druggable Genome, Transmembrane
Protein Pathways Alzheimer's disease

Citations (2)

Documents

Other Versions

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