Amyloid Precursor Protein (APP) (NM_201414) Human Recombinant Protein
SKU
TP315147
Recombinant protein of human amyloid beta (A4) precursor protein (APP), transcript variant 3, 20 µg
$867.00
In Stock*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 76.9 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_958817 |
| Locus ID | 351 |
| UniProt ID | P05067 |
| Cytogenetics | 21q21.3 |
| RefSeq Size | 3416 |
| RefSeq ORF | 2085 |
| Synonyms | AAA; ABETA; ABPP; AD1; alpha-sAPP; APPI; CTFgamma; CVAP; PN-II; PN2; preA4 |
| Summary | This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. provided by RefSeq, Aug 2014 |
| Protein Categories | Chemokines, Growth Factors, Intracellular Proteins, Membrane Proteins, Nervous system: Neurodegenerative diseases, Secreated Proteins |
| Protein Families | Druggable Genome, Transmembrane |
| Protein Pathways | Alzheimer's disease |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "Amyloid Precursor Protein" proteins (11)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| PH309575 | APP MS Standard C13 and N15-labeled recombinant protein (NP_958816) | 10 ug |
$3,360.00
|
|
| PH315147 | APP MS Standard C13 and N15-labeled recombinant protein (NP_958817) | 10 ug |
$3,360.00
|
|
| LC404408 | Lyophilized APP HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LC404409 | Lyophilized APP HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LC424694 | Lyophilized APP HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LC427815 | Lyophilized APP HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY404408 | Transient overexpression lysate of amyloid beta (A4) precursor protein (APP), transcript variant 2 (as WB positive control) | 100 ug |
$436.00
|
|
| LY404409 | Transient overexpression lysate of amyloid beta (A4) precursor protein (APP), transcript variant 3 (as WB positive control) | 100 ug |
$665.00
|
|
| LY424694 | Transient overexpression lysate of amyloid beta (A4) precursor protein (APP), transcript variant 1 (as WB positive control) | 100 ug |
$665.00
|
|
| LY427815 | Transient overexpression lysate of amyloid beta (A4) precursor protein (APP), transcript variant 5 (as WB positive control) | 100 ug |
$436.00
|
|
| TP309575 | Recombinant protein of human amyloid beta (A4) precursor protein (APP), transcript variant 2, 20 µg | 20 ug |
$867.00
|
|
Citations
Amyloid β and Amyloid Precursor Protein Synergistically Suppress Large-Conductance Calcium-Activated Potassium Channel in Cortical Neurons
Yamamoto, Yamamoto, Kato
Front Aging Neurosci (2021) 13, 660319 DOI: 10.3389/fnagi.2021.660319
Yamamoto, Yamamoto, Kato
Front Aging Neurosci (2021) 13, 660319 DOI: 10.3389/fnagi.2021.660319
Cited by 16
AI Summary: OriGene’s full-length APP protein was used for intracellular injection experiments to investigate the role of amyloid precursor protein in suppressing BK channel activity in cortical neurons.
Snippet: and injected intracellularly by diffusion: full-length APP (52 nM, OriGene),
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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