E2F1 (NM_005225) Human Recombinant Protein

CAT#: TP308247

Recombinant protein of human E2F transcription factor 1 (E2F1)

 Product Datasheet for 'TP308247'

 Cited in 1 publication.

  View other "E2F1" proteins (3)

USD 748.00

In Stock

    • 20 ug

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Product Data
Description Recombinant protein of human E2F transcription factor 1 (E2F1)
Species Human
Expression Host HEK293T
Expression cDNA Clone or AA Sequence Recombinant protein was produced with TrueORF clone, RC208247. Click on the TrueORF clone link to view cDNA and protein sequences.
Predicted MW 46.7 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. Store at –80C. Avoid repeated freeze-thaw cycles. Stable for 3 months from receipt of products under proper storage and handling conditions.
Bioactivity WB standard (PMID: 26639898)
Preparation Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Reference Data
RefSeq NP_005216
Locus ID 1869
Refseq Size 2486
Cytogenetics 20q11.22
Refseq ORF 1311
Synonyms E2F-1; RBAP1; RBBP3; RBP3
Summary The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. [provided by RefSeq, Jul 2008]
Protein Families Transcription Factors, Druggable Genome
Protein Pathways Cell cycle, Pathways in cancer, Pancreatic cancer, Glioma, Prostate cancer, Melanoma, Bladder cancer, Chronic myeloid leukemia, Small cell lung cancer, Non-small cell lung cancer

Citations (1)


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