RRM2 (NM_001034) Human Recombinant Protein

CAT#: TP305718

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Recombinant protein of human ribonucleotide reductase M2 polypeptide (RRM2)


 Product Datasheet for 'TP305718'

 Cited in 1 publication.

  View other "RRM2" proteins (7)

USD 748.00


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Size
    • 20 ug


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Specifications

Product Data
Description Recombinant protein of human ribonucleotide reductase M2 polypeptide (RRM2)
Species Human
Expression Host HEK293T
Tag C-Myc/DDK
Predicted MW 44.7 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Bioactivity Binding assay (PMID: 29765556)
Preparation Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Reference Data
RefSeq NP_001025
Locus ID 6241
Refseq Size 2500
Cytogenetics 2p25.1
Refseq ORF 1167
Synonyms R2; RR2; RR2M
Summary This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Sep 2009]
Protein Families Druggable Genome
Protein Pathways Glutathione metabolism, Metabolic pathways, p53 signaling pathway, Purine metabolism, Pyrimidine metabolism

Citations (1)

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