RRM2 (NM_001034) Human Recombinant Protein
$7,820.00
6 Weeks*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 44.7 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Bioactivity | Binding assay (PMID: 29765556) |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_001025 |
| Locus ID | 6241 |
| UniProt ID | P31350 |
| Cytogenetics | 2p25.1 |
| RefSeq Size | 2500 |
| RefSeq ORF | 1167 |
| Synonyms | C2orf48; R2; RR2; RR2M |
| Summary | This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X. provided by RefSeq, Sep 2009 |
| Protein Categories | Membrane Proteins |
| Protein Families | Druggable Genome |
| Protein Pathways | Glutathione metabolism, Metabolic pathways, p53 signaling pathway, Purine metabolism, Pyrimidine metabolism |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Citations
Antibody-assisted target identification reveals afatinib, an EGFR covalent inhibitor, down-regulating ribonucleotide reductase
Yu, Chou, Tu et al
Oncotarget (2018) 9 (30), 21512-21529 DOI: 10.18632/oncotarget.25177
Yu, Chou, Tu et al
Oncotarget (2018) 9 (30), 21512-21529 DOI: 10.18632/oncotarget.25177
Snippet: RRM1, anti-RRM2 (Santa Cruz Biotechnology, Inc., Dallas, TX);DMEM, RPMI 1649 medium, fetal bovine serum (HyClone Laboratories, Inc., South Logan, UT);human RRM1 and RRM2 produced from HEK293 cells (OriGene Technologies, Inc., Rockville, MD);anti-EGFR, anti-GAPDH, DNA damage antibody sampler kit (Cell Signaling Technology, Boston, MA);C18 Zip-tip, Amicon Ultra-15 centrifugal filters, anti-phosp
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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