IDE (NM_004969) Human Mass Spec Standard
$3,360.00
3 Weeks*
Specifications
| Product Data | |
| Tag | C-Myc/DDK |
|---|---|
| Species | Human |
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | RC220700 |
| Predicted MW | 117.8 kDa |
| Protein Sequence | |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Labeling Method | Labeled with U- 13C6, 15N4-L-Arginine and U- 13C6, 15N2-L-Lysine |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3 |
| Storage | Store at -80°C. Avoid repeated freeze-thaw cycles. |
| Stability | Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_004960 |
| RefSeq Size | 3279 |
| RefSeq ORF | 3057 |
| Synonyms | INSULYSIN |
| Locus ID | 3416 |
| UniProt ID | P14735 |
| Cytogenetics | 10q23.33 |
| Summary | This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.provided by RefSeq, Sep 2009 |
| Protein Families | Druggable Genome, Protease |
| Protein Pathways | Alzheimer's disease |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "IDE" proteins (5)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| LC401545 | Lyophilized IDE HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY401545 | Transient overexpression lysate of insulin-degrading enzyme (IDE), transcript variant 1 (as WB positive control) | 100 ug |
$665.00
|
|
| TP320700 | Recombinant protein of human insulin-degrading enzyme (IDE), 20 µg | 20 ug |
$737.00
|
|
| TP721043 | Purified recombinant protein of Human insulin-degrading enzyme (IDE), transcript variant 1 | 10 ug |
$340.00
|
|
| TP724587 | Recombinant human Insulysin/IDE protein | 10 ug |
$325.00
|
|
Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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