IDE Mouse Monoclonal Antibody [Clone ID: OTI4E5]
$447.00
In Stock*
Specifications
| Product Data | |
| Clone Name | OTI4E5 |
|---|---|
| Application | WB |
| Recommended Dilution | WB 1:500 |
| Reactivity | Human, Monkey, Mouse, Rat |
| Antibody Host | Mouse |
| Isotype | IgG2b |
| Clonality | Monoclonal |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 800-1019 of human IDE (NP_004960) produced in E.coli. |
| Buffer | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide |
| Concentration | 1 mg/ml |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 117.8 kDa |
| Gene Name | insulin degrading enzyme |
| Database Link | |
| Background | This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified. provided by RefSeq, Sep 2009 |
| Synonyms | INSULYSIN |
| Reference Data | |
| Protein Categories | Enzyme: Peptidases, Intracellular Proteins, Secreated Proteins |
| Protein Families | Druggable Genome, Protease |
| Protein Pathways | Alzheimer's disease |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other "OTI4E5" antibodies (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| CF811776 | Carrier-free (BSA/glycerol-free) IDE mouse monoclonal antibody,clone OTI4E5 | 100 ug |
$620.00
|
|
| TA811776AM | IDE mouse monoclonal antibody,clone OTI4E5, Biotinylated | 100 ul |
$509.00
|
|
| TA811776BM | IDE mouse monoclonal antibody,clone OTI4E5, HRP conjugated | 100 ul |
$509.00
|
|
| TA811776S | IDE mouse monoclonal antibody,clone OTI4E5 | 30 ul |
$200.00
|
|
Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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