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Ucp1 Mouse Gene Knockout Kit (CRISPR)

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SKU
KN318648BN
Ucp1 - mouse gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Other products for "Ucp1 or BC012701"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control
Vector mBFP-Neo
Target Symbol Ucp1
Locus ID 22227
Components

KN318648G1, Ucp1 gRNA vector 1 in pCas-Guide CRISPR vector

KN318648G2, Ucp1 gRNA vector 2 in pCas-Guide CRISPR vector

KN318648BND, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_009463
UniProt ID P12242
Synonyms AI385626; Slc25a7; Ucp
Summary Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates to non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance (PubMed:9139827, PubMed:19187776, PubMed:23063128, PubMed:27027295). Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP (PubMed:23063128). Regulates the production of reactive oxygen species/ROS by mitochondria (PubMed:20416274, PubMed:20466728).UniProtKB/Swiss-Prot Function
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Other Versions
SKU Description Size Price
GA204530 Ucp1 CRISPRa kit - CRISPR gene activation of mouse uncoupling protein 1 (mitochondrial, proton carrier) 1 kit
$1,657.00
KN318648 Ucp1 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN318648LP Ucp1 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN318648RB Ucp1 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN518648 Ucp1 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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