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Trp53 Mouse Gene Knockout Kit (CRISPR)

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SKU
KN318278RB
Trp53 - mouse gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Other products for "Trp53 or BC005448"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 RFP-BSD donor, 1 scramble control
Vector RFP-BSD
Target Symbol Trp53
Locus ID 22059
Components

KN318278G1, Trp53 gRNA vector 1 in pCas-Guide CRISPR vector

KN318278G2, Trp53 gRNA vector 2 in pCas-Guide CRISPR vector

KN318278RBD, donor DNA containing left and right homologous arms and RFP-BSD functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_001127233, NM_011640
UniProt ID P02340
Synonyms bbl; bfy; bhy; p44; p53; Tp53
Summary This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mice deficient for this gene are developmentally normal but are susceptible to spontaneous tumors. Evidence to date shows that this gene contains one promoter, in contrast to alternative promoters of the human gene, and transcribes a few of splice variants which encode different isoforms, although the biological validity or the full-length nature of some variants has not been determined. provided by RefSeq, Jul 2008
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Documents
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Other Versions
SKU Description Size Price
GA204449 Trp53 CRISPRa kit - CRISPR gene activation of mouse transformation related protein 53 1 kit
$1,657.00
KN318278 Trp53 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN318278BN Trp53 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN318278LP Trp53 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN518278 Trp53 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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