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Tgfb1 Mouse Gene Knockout Kit (CRISPR)

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SKU
KN317482
Tgfb1 - mouse gene knockout kit via CRISPR
  $1,657.00
4 Weeks*

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Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 GFP-puro donor, 1 scramble control
Vector GFP-puro
Target Symbol Tgfb1
Locus ID 21803
Components

KN317482G1, Tgfb1 gRNA vector 1 in pCas-Guide CRISPR vector

KN317482G2, Tgfb1 gRNA vector 2 in pCas-Guide CRISPR vector

KN317482D, donor DNA containing left and right homologous arms and GFP-puro functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_011577
UniProt ID P04202
Synonyms TGF-beta1; Tgfb; Tgfb-1; TGFbeta1
Summary This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. Mice lacking a functional copy of this gene develop severe multifocal inflammatory disease, yolk sac defects and colon cancer. provided by RefSeq, Aug 2016
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Other Versions
SKU Description Size Price
GA204317 Tgfb1 CRISPRa kit - CRISPR gene activation of mouse transforming growth factor, beta 1 1 kit
$1,657.00
KN517482 Tgfb1 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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