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Tet2 Mouse Gene Knockout Kit (CRISPR)

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SKU
KN317423LP
Tet2 - mouse gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Other products for "Tet2 or NM_001040400"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control
Vector Luciferase-Puro
Target Symbol Tet2
Locus ID 214133
Components

KN317423G1, Tet2 gRNA vector 1 in pCas-Guide CRISPR vector

KN317423G2, Tet2 gRNA vector 2 in pCas-Guide CRISPR vector

KN317423LPD, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_001040400, NM_001346736, NM_145989
UniProt ID Q4JK59
Synonyms Ayu17-449; E130014J05Rik; mKIAA1546
Summary Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT.UniProtKB/Swiss-Prot Function
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Documents
Resources
Other Versions
SKU Description Size Price
GA213194 Tet2 CRISPRa kit - CRISPR gene activation of mouse tet methylcytosine dioxygenase 2 1 kit
$1,657.00
KN317423 Tet2 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN317423BN Tet2 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN317423RB Tet2 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN517423 Tet2 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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