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Rnf31 Mouse Gene Knockout Kit (CRISPR)

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SKU
KN314948BN
Rnf31 - mouse gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

Frequently Bought Together (3)

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Other products for "Rnf31 or BC057595"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control
Vector mBFP-Neo
Target Symbol Rnf31
Locus ID 268749
Components

KN314948G1, Rnf31 gRNA vector 1 in pCas-Guide CRISPR vector

KN314948G2, Rnf31 gRNA vector 2 in pCas-Guide CRISPR vector

KN314948BND, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_194346
UniProt ID Q924T7
Synonyms AL033293; BC031509; Flj10111; HOIP; mFLJ00217; Paul
Summary E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:28701375). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (By similarity). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:28701375). Recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (By similarity). Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis (By similarity). Binds polyubiquitin of different linkage types (By similarity).UniProtKB/Swiss-Prot Function
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Documents
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Other Versions
SKU Description Size Price
GA215949 Rnf31 CRISPRa kit - CRISPR gene activation of mouse ring finger protein 31 1 kit
$1,657.00
KN314948 Rnf31 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN314948LP Rnf31 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN314948RB Rnf31 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN514948 Rnf31 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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