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Pik3ca Mouse Gene Knockout Kit (CRISPR)

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SKU
KN313294BN
Pik3ca - mouse gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

Frequently Bought Together (3)

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Other products for "Pik3ca or BC089038"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control
Vector mBFP-Neo
Target Symbol Pik3ca
Locus ID 18706
Components

KN313294G1, Pik3ca gRNA vector 1 in pCas-Guide CRISPR vector

KN313294G2, Pik3ca gRNA vector 2 in pCas-Guide CRISPR vector

KN313294BND, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_008839
UniProt ID P42337
Synonyms 6330412C24Rik; caPI3K; p110; p110alpha
Summary Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF. Regulates invadopodia formation through the PDPK1-AKT1 pathway. Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway. Also has serine-protein kinase activity: phosphorylates PIK3R1 (p85alpha regulatory subunit), EIF4EBP1 and HRAS. Plays a role in the positive regulation of phagocytosis and pinocytosis (PubMed:19604150).UniProtKB/Swiss-Prot Function
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Documents
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Other Versions
SKU Description Size Price
GA203215 Pik3ca CRISPRa kit - CRISPR gene activation of mouse phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha 1 kit
$1,657.00
KN313294 Pik3ca - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN313294LP Pik3ca - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN313294RB Pik3ca - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN513294 Pik3ca - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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