Nr1d1 Mouse Gene Knockout Kit (CRISPR)

SKU KN311193RB

Nr1d1 - mouse gene knockout kit via CRISPR, HDR mediated

Product Data

• Format: 2 gRNA vectors, 1 RFP-BSD donor, 1 scramble control
• Vector: RFP-BSD
• Target Symbol: Nr1d1
• Locus ID: 217166
• Components:

  KN311193G1, Nr1d1 gRNA vector 1 in pCas-Guide CRISPR vector

  KN311193G2, Nr1d1 gRNA vector 2 in pCas-Guide CRISPR vector

  KN311193RBD, donor DNA containing left and right homologous arms and RFP-BSD functional cassette.

  GE100003, scramble sequence in pCas-Guide vector

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_145434
• UniProt ID: Q3UV55
• Synonyms: A530070C09Rik; R75201
• Summary: This gene encodes a transcription factor that is a member of the nuclear receptor subfamily 1. The encoded protein is a ligand-sensitive transcription factor that negatively regulates the expression of core clock proteins. In particular this protein represses the circadian clock transcription factor aryl hydrocarbon receptor nuclear translocator-like protein 1 (Arntl). This protein may also be involved in regulating genes that function in metabolic, inflammatory and cardiovascular processes. [provided by RefSeq, Feb 2014]
• Shipping: Ambient