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Nlrp12 Mouse Gene Knockout Kit (CRISPR)

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SKU
KN311043LP
Nlrp12 - mouse gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

Frequently Bought Together (4)

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Other products for "Nlrp12 or BC116252"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control
Vector Luciferase-Puro
Target Symbol Nlrp12
Locus ID 378425
Components

KN311043G1, Nlrp12 gRNA vector 1 in pCas-Guide CRISPR vector

KN311043G2, Nlrp12 gRNA vector 2 in pCas-Guide CRISPR vector

KN311043LPD, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_001033431
UniProt ID E9Q5R7
Synonyms Nalp12; PYPAF7
Summary Plays an essential role as an potent mitigator of inflammation (PubMed:26521018, PubMed:30559449). Primarily expressed in dendritic cells and macrophages, inhibits both canonical and non-canonical NF-kappa-B and ERK activation pathways (PubMed:30559449). Functions as a negative regulator of NOD2 by targeting it to degradation via the proteasome pathway (PubMed:30559449). In turn, promotes bacterial tolerance (PubMed:30559449). Inhibits also the DDX58-mediated immune signaling against RNA viruses by reducing the E3 ubiquitin ligase TRIM25-mediated 'Lys-63'-linked DDX58 activation but enhancing the E3 ubiquitin ligase RNF125-mediated 'Lys-48'-linked DDX58 degradation (By similarity). Acts also as a negative regulator of inflammatory response to mitigate obesity and obesity-associated diseases in adipose tissue (PubMed:30212649).UniProtKB/Swiss-Prot Function
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Other Versions
SKU Description Size Price
GA216994 Nlrp12 CRISPRa kit - CRISPR gene activation of mouse NLR family, pyrin domain containing 12 1 kit
$1,657.00
KN311043 Nlrp12 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN311043BN Nlrp12 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN311043RB Nlrp12 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN511043 Nlrp12 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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