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N6amt1 Mouse Gene Knockout Kit (CRISPR)

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SKU
KN310676BN
N6amt1 - mouse gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

Frequently Bought Together (3)

MR227618 N6amt1 (Myc-DDK-tagged) - Mouse N-6 adenine-specific DNA methyltransferase 1 (putative) (N6amt1), transcript variant 1
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Other products for "N6amt1 or BC098330"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control
Vector mBFP-Neo
Target Symbol N6amt1
Locus ID 67768
Components

KN310676G1, N6amt1 gRNA vector 1 in pCas-Guide CRISPR vector

KN310676G2, N6amt1 gRNA vector 2 in pCas-Guide CRISPR vector

KN310676BND, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_001159331, NM_026366
UniProt ID Q6SKR2
Synonyms 5830445C04Rik; Hemk2; Pred28
Summary Methyltransferase that can methylate both proteins and DNA, and to a lower extent, arsenic (PubMed:20606008, PubMed:26797129). Catalytic subunit of a heterodimer with TRMT112, which catalyzes N5-methylation of Glu residue of proteins with a Gly-Gln-Xaa-Xaa-Xaa-Arg motif (PubMed:26797129). Methylates ETF1 on 'Gln-185'; ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated (PubMed:20606008, PubMed:26797129). Also acts as a N(6)-adenine-specific DNA methyltransferase by mediating methylation of DNA on the 6th position of adenine (N(6)-methyladenosine) (By similarity). N(6)-methyladenosine (m6A) DNA is significantly enriched in exonic regions and is associated with gene transcriptional activation (By similarity). May also play a role in the modulation of arsenic-induced toxicity by mediating the conversion of monomethylarsonous acid (3+) into the less toxic dimethylarsonic acid (By similarity). It however only plays a limited role in arsenic metabolism compared with AS3MT (By similarity).UniProtKB/Swiss-Prot Function
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Documents
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Other Versions
SKU Description Size Price
GA207505 N6amt1 CRISPRa kit - CRISPR gene activation of mouse N-6 adenine-specific DNA methyltransferase 1 (putative) 1 kit
$1,657.00
KN310676 N6amt1 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN310676LP N6amt1 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN310676RB N6amt1 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN510676 N6amt1 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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