Ldlr Mouse Gene Knockout Kit (CRISPR)

CAT#: KN309204RB

Ldlr - mouse gene knockout kit via CRISPR, HDR mediated

Product Images

Specifications

Product Data

• Format: 2 gRNA vectors, 1 RFP-BSD donor, 1 scramble control
• Donor DNA: RFP-BSD
• Symbol: Ldlr
• Locus ID: 16835
• Components:

  KN309204G1, Ldlr gRNA vector 1 in pCas-Guide CRISPR vector

  KN309204G2, Ldlr gRNA vector 2 in pCas-Guide CRISPR vector

  KN309204RBD, donor DNA containing left and right homologous arms and RFP-BSD functional cassette.

  GE100003, scramble sequence in pCas-Guide vector

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_001252658, NM_001252659, NM_010700
• UniProt ID: P35951
• Synonyms: Hlb301
• Summary: Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits.[UniProtKB/Swiss-Prot Function]