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Lats1 Mouse Gene Knockout Kit (CRISPR)

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SKU
KN309147LP
Lats1 - mouse gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

Frequently Bought Together (3)

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Other products for "Lats1 or NM_010690"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control
Vector Luciferase-Puro
Target Symbol Lats1
Locus ID 16798
Components

KN309147G1, Lats1 gRNA vector 1 in pCas-Guide CRISPR vector

KN309147G2, Lats1 gRNA vector 2 in pCas-Guide CRISPR vector

KN309147LPD, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_010690
UniProt ID Q8BYR2
Synonyms AW208599
Summary Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function. Plays a role in mammary gland epithelial cells differentiation, both through the Hippo signaling pathway and the intracellular estrogen receptor signaling pathway by promoting the degradation of ESR1.UniProtKB/Swiss-Prot Function
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Documents
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Other Versions
SKU Description Size Price
GA202419 Lats1 CRISPRa kit - CRISPR gene activation of mouse large tumor suppressor 1 kit
$1,657.00
KN309147 Lats1 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN309147BN Lats1 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN309147RB Lats1 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN509147 Lats1 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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