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Gnas Mouse Gene Knockout Kit (CRISPR)

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SKU
KN307068RB
Gnas - mouse gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Other products for "Gnas or NM_001077507"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 RFP-BSD donor, 1 scramble control
Vector RFP-BSD
Target Symbol Gnas
Locus ID 14683
Components

KN307068G1, Gnas gRNA vector 1 in pCas-Guide CRISPR vector

KN307068G2, Gnas gRNA vector 2 in pCas-Guide CRISPR vector

KN307068RBD, donor DNA containing left and right homologous arms and RFP-BSD functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_001077507, NM_001077510, NM_010309, NM_010310, NM_019690, NM_022000, NM_201616, NM_201617, NM_201618, NR_003258
UniProt ID P63094
Synonyms 5530400H20Rik; A930027G11Rik; C130027O20Rik; Galphas; Gnas1; Gnasxl; GPSA; Gs-alpha
Summary This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, which is commonly found in imprinted genes and correlates with transcript expression. This gene has an antisense transcript. One of the transcripts produced from this locus, and the antisense transcript, are both paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Additional transcript variants have been found for this gene, but the full-length nature and/or biological validity of some variants have not been determined. provided by RefSeq, Jun 2015
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Documents
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Other Versions
SKU Description Size Price
GA201654 Gnas CRISPRa kit - CRISPR gene activation of mouse GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus 1 kit
$1,657.00
KN307068 Gnas - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN307068BN Gnas - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN307068LP Gnas - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN507068 Gnas - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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