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PD-L1 (Cd274) Mouse Gene Knockout Kit (CRISPR)

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SKU
KN302893LP
Cd274 - mouse gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control
Vector Luciferase-Puro
Target Symbol PD-L1
Locus ID 60533
Components

KN302893G1, PD-L1 gRNA vector 1 in pCas-Guide CRISPR vector

KN302893G2, PD-L1 gRNA vector 2 in pCas-Guide CRISPR vector

KN302893LPD, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_021893
UniProt ID Q9EP73
Synonyms A530045L16Rik; B7h1; Pdcd1l1; Pdcd1lg1; Pdl1
Summary The protein encoded by this gene is an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Mice deficient for this gene display a variety of phenotypes including decreased allogeneic fetal survival rates and severe experimental autoimmune encephalomyelitis. provided by RefSeq, Sep 2015
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Other Versions
SKU Description Size Price
GA206402 Cd274 CRISPRa kit - CRISPR gene activation of mouse CD274 antigen 1 kit
$1,657.00
KN302893 Cd274 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN302893BN Cd274 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN302893RB Cd274 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN502893 Cd274 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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