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Alox12 Mouse Gene Knockout Kit (CRISPR)

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SKU
KN301155BN
Alox12 - mouse gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

Frequently Bought Together (3)

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Other products for "Alox12 or NM_001331118"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control
Vector mBFP-Neo
Target Symbol Alox12
Locus ID 11684
Components

KN301155G1, Alox12 gRNA vector 1 in pCas-Guide CRISPR vector

KN301155G2, Alox12 gRNA vector 2 in pCas-Guide CRISPR vector

KN301155BND, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_001331118, NM_007440
UniProt ID P39655
Synonyms 9930022G08Rik; Alox12p; P-12LO
Summary Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE but can also metabolize linoleic acid. Has a dual activity since it also converts leukotriene A4/LTA4 into both the bioactive lipoxin A4/LXA4 and lipoxin B4/LXB4. Through the production of specific bioactive lipids like (12S)-HPETE it regulates different biological processes including platelet activation. It also probably positively regulates angiogenesis through regulation of the expression of the vascular endothelial growth factor. Plays a role in apoptotic process, promoting the survival of vascular smooth muscle cells for instance. May also play a role in the control of cell migration and proliferation.UniProtKB/Swiss-Prot Function
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Other Versions
SKU Description Size Price
GA200165 Alox12 CRISPRa kit - CRISPR gene activation of mouse arachidonate 12-lipoxygenase 1 kit
$1,657.00
KN301155 Alox12 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN301155LP Alox12 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN301155RB Alox12 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN501155 Alox12 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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