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DUOX1 Human Gene Knockout Kit (CRISPR)

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SKU
KN223832
DUOX1 - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

Frequently Bought Together (4)

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Other products for "DUOX1 or NM_017434"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 GFP-puro donor, 1 scramble control
Vector GFP-puro
Target Symbol DUOX1
Locus ID 53905
Components

KN223832G1, DUOX1 gRNA vector 1 in pCas-Guide CRISPR vector, Target Sequence: GGCTCTAGCATGGACACTTC

KN223832G2, DUOX1 gRNA vector 2 in pCas-Guide CRISPR vector, Target Sequence: CCCTCTGGGTGAGTACAGAT

KN223832D, donor DNA containing left and right homologous arms and GFP-puro functional cassette.

Homologous arm and GFP-puro sequences:

pUC vector backbone in gray; Left arm sequence in blue; GFP-puro in green; Right arm in violet

TTTGCCCAAC ACCTGTCACT TGCTTTGAAT TAAACCTCCT TCTCACATTT GATTCTGGCA ACCATGCTTA GAAGTAAACA GTTCAGGCAT ATTTGCTCCC ATAGCTGGAA GAGGAAAACA AGGATCAGAT TGGAGAAGTG ATTTATCTAA GATCCCACAG TGGACTGGGA GCAGCACTGA GACCTCAGCC TAGTCTCCTG ATCCCCAAGC AGGGCCCTGC CTAAGGAACA CACTCTGCAG AGTGCTGGGC CAAAGCAGGG TTTTCCAACT AATCTTAGAA GGTAAAGTCC ATGAAGGTAT GTACCAGGGA TTTCTGTTTG TTTTGTTCGT CACTTAATCT CCAGTGTCTA TGTCAGTGGC TGGTATGTAG TGGTGCTCAT GAAGTATTTG CCGAATCAAT TAAAGAATTT TCGGAAAGAG TGAGTCTCTT GAACTTTGCT ACCTACTGTG ACCTTGGCCC AGCCCCAGGC CTTGATTCAC AGAGGCCTGC AGAGTCTTTC ACCTGATTCT TCTGAGTAGC TGGGGCTCAT TCTTTGCCTG TCTTTTTCTA GGGTCTCCAT TTTGGGACAT TCTAATCCCT GAGCCCCTAT TATTTTCATC GGAGGAGAAG CATGGTTAGG AGCAGAGGAA CCCAGCATCC TCTGGGCTCC CCCAAGGACA GGATCCATTT GATATTCATC TGTATCTTTA GTCTCTAGCT GACACAGTGC CCTGCACATG AGAGTTGCTC ATTTCTAGCT GTTGAAGAAA TAGATGGATA ATGGAATGAA AATTATCCCC AAATACACAG AATTAGGGAG CCTTCAGCTG CTGTCAGCAC TTTCTCTTTT ATTCTTACAG TTTGGGGGCC CTTTCTCTCT CCTCTCTCTT CTCTTGTTTT CCATAAAGTG AGGGCCTCTG ACTCAAAATA GGAAAAGATT GATTAGACAC ATAAGACAAT AAAGGATCTT GGGGTCAGAT TGGACCCAAA GCTGAAGGGG AGTCATCAAT ATGTTTAAAC ATTATGATGA AAAACAAAAG CAATATCTTC CATAAGAGTT TCATGTTGCT GCCTTCAGTA GACAGTTTCT TGCTGGAATC TGAGGCTGCT CTCTGCAGTC CGGATCTCTG TGGAGGGAAG TGGGCCTACA GTGCCACAGT TAAAGTTAAA AGATCAAGTC CCTGATCACT GGGGATGGGA GATGCAAAAG CAGAAAGCAG

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_017434, NM_175940
UniProt ID Q9NRD9
Synonyms LNOX1; NOXEF1; THOX1
Summary The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes proteins encoded by this gene and the similar DUOX2 gene. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. This protein generates hydrogen peroxide and thereby plays a role in the activity of thyroid peroxidase, lactoperoxidase, and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. provided by RefSeq, Jul 2012
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Documents
Resources
Other Versions
SKU Description Size Price
GA110038 DUOX1 CRISPRa kit - CRISPR gene activation of human dual oxidase 1 1 kit
$1,657.00
KN223832BN DUOX1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN223832LP DUOX1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN223832RB DUOX1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN423832 DUOX1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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