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CIITA Human Gene Knockout Kit (CRISPR)

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SKU
KN222253BN
CIITA - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Other products for "CIITA or NM_000246"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control
Vector mBFP-Neo
Target Symbol CIITA
Locus ID 4261
Components

KN222253G1, CIITA gRNA vector 1 in pCas-Guide CRISPR vector

KN222253G2, CIITA gRNA vector 2 in pCas-Guide CRISPR vector

KN222253BND, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_000246, NM_001286402, NM_001286403, NR_104444
UniProt ID P33076
Synonyms C2TA; CIITAIV; MHC2TA; NLRA
Summary This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. Several transcript variants encoding different isoforms have been found for this gene. provided by RefSeq, Nov 2013
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Documents
Resources
Other Versions
SKU Description Size Price
GA102905 CIITA CRISPRa kit - CRISPR gene activation of human class II major histocompatibility complex transactivator 1 kit
$1,657.00
KN222253 CIITA - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN222253LP CIITA - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN222253RB CIITA - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN422253 CIITA - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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